CBD and Cancer Patients


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People with blood cancers may be at higher risk of prolonged infection and death from COVID-19 than people with solid tumors. That is because patients with blood cancers often have abnormal or depleted levels of immune cells that produce antibodies against viruses. However, it's important to look at all the other factors accompanying a cancer diagnosis like age and measures of frailty. Despite immunotherapy having no likely effect on COVID-19 outcomes, many of these patients will find themselves in the high-risk group for various other reasons. Dexamethasone is commonly used as an antiemetic for patients with cancer and is recommended for the treatment of certain patients with COVID-19.
More recently, scientists reported that THC and other cannabinoids such as CBD slow growth and/or cause death in certain types of cancer cells growing in lab dishes. Some animal studies also suggest certain cannabinoids may slow growth and reduce spread of some forms of cancer. -cancer.org
A new study published in Science Advances reports evidence that cannabidiol (CBD), a product of the cannabis plant, can inhibit infection by SARS-CoV-2 in human cells and in mice. CBD inhibits replication in part by up-regulating the host IRE1α ribonuclease endoplasmic reticulum (ER). SARS-CoV-2 is the virus that causes COVID-19.
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El uso del CBD o Cannabis Medicinal para la fibromialgia trae múltiples beneficios. En este video el Dr. Alejandro Garzón - Médico experto en el uso del CBD nos explica detalles acerca de la molécula, sus efectos en nuestro cuerpo, indicaciones, contraindicaciones y efectos adversos.
La fibromialgia es una enfermedad crónica que produce dolor generalizado de difícil manejo asociado a algunos síntomas cardinales como la alteración del sueño, fatiga y dificultades cognitivas (fibroniebla); sin embargo se han llegado a describir más de 100 síntomas de la fibromialgia.
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What are cannabinoids?
Cannabinoids are chemicals found in the cannabis plant. The most well-known cannabinoid is THC which is the primary psychoactive compound in cannabis. A lot of people consider this the recreational portion of the cannabis plant. The next cannabinoid I will be talking about is CBD - cannabidiol, which is getting a lot of air play as it is helping with seizures, it is a non-pyscho-active. CBD - cannabidiol - is another major constituent of the plant. As i mentioned earlier, patients, people, doctors will come and say, I don't want to get high I want the medical portion of the plant. Actually, there are about 120 different cannabinoids isolated in the cannabis plant and they are all medical, they are all beneficial, they are all exhibiting various effects from fighting cancer, to sleep disorders, PTSD, brain disorders - the list goes on and on. Remember, cannabis is not a one size fits all. What works for a friend or family member with the same ailment, may not work for you. Do your research, meet with a medical professional, and see what cannabinoid is best for you. Visit us at: https://www.unitedpatientsgroup.com
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WHAT IS CANNABIS OIL AND WHERE DOES IT COME FROM?
Cannabis oil is a thick, sticky substance composed of cannabinoids, such as THC and CBD, which is obtained from cannabis flowers using a solvent extraction procedure.
It is the most concentrated form of cannabis products, which makes cannabis oil the most powerful.
The oil can be vaporized into the lungs, ingested orally, applied topically or used as a suppository. It can also be mixed with creams or salves for beauty treatments, and other external uses.
The cannabis plant originated from Central Asia, and is one of the oldest, mental stimulating drugs known to mankind.
The beginnings of its use are difficult to trace, since the plant was cultivated and consumed long before the appearance of writing. According to archeological discoveries, the cannabis plant has been known in China at least since around 4000 BC.
Some of the diseases and conditions that cannabis oil has been used for include: Crohn’s disease, diabetes, gout, pain relief, glaucoma, migraines, Dravet syndrome, asthma, Doose syndrome, epilepsy, anorexia, rheumatoid arthritis, multiple sclerosis, psoriasis, opioid dependence, strokes, head trauma, Alzheimer’s disease, Parkinson’s disease, HIV dementia and — what we will be focusing on — cancer.
HOW DOES CBD KILL CANCER?
Simply put, when THC connects to the CB1 or CB2 cannabinoid receptor site on the cancer cell, it induces an increase in ceramide synthesis that leads to cell death.
A normal cell does not produce ceramide when it is near THC; therefore it is not affected by the cannabinoid.
The reason the cancer cell dies is not because of the cytotoxic chemicals, but because there of a small shift in the mitochondria.
The purpose of the mitochondria within a cell is to produce energy for the cell to use. As the ceramide is produced, it turns up the sphingolipid rheostat.
This production increases the mitochondrial membrane permeability to cytochrome c, which is vital protein in energy synthesis. The cytochrome c is then pushed out of the mitochondria, which ultimately kills the source of energy for that particular cell.
The presence of ceramide leaves no possibility of cancer cell survival. This is because it causes genotoxic stress in the cancer cell that generates a protein call p53, which disrupts the calcium metabolism in the mitochondria.
Ceramide also disrupts the cell’s digestive system that produces nutrients for all cell function, and actively inhibits pro-survival pathways.
The key to the cancer killing process is the accumulation of ceramide in the system.
This means that by taking any amount of CBD and THC, at a steady rate over a period of time, the patient will keep metabolic pressure on these cancer cell death pathways.
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"Therapeutic Applications of Cannabinoids in Oncology" presented by prof. Manuel Guzmán at Cannafest 2014:
Cannabinoids, the active components of cannabis and their derivatives, exert palliative effects in cancer patients.The use of cannabinoids in medicine, however, is limited by their psychoactive effects, which are well tolerated by some patients, but not by others. At the moment there is not solid evidence yet to prove that cannabinoids can be effective anti-tumour drugs to treat cancer in patients, but intense research is ongoing around the world.
Don't miss the next Cannafest conference, 4th - 6th November 2015 in Prague. All lectures are held in Czech or English and are simultaneously translated.
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Dr. Cristina Sánchez speaking at Cannafest about atitumoral effects od cannabinoids.
Abstract: There is compelling evidence indicating that cancer is one of the pathologies that may obtain clinical benefit from cannabis-related compounds. First, it is well known that cannabinoids have palliative effects in cancer patients. In particular, they inhibit chemotherapy-induced nausea and vomiting, they inhibit cancer-associated pain and they stimulate appetite and attenuate wasting. But the therapeutic potential of cannabinoids in oncology might not be restricted to their aforementioned palliative actions. Thus, numerous studies carried out during the past few years have provided evidence showing that THC and other cannabinoids induce the death of cancer cells in culture and reduce tumor growth and progression in a wide range of animal models of cancer. The mechanisms of anti-tumor action include the induction of cancer cell death, an effect that is not produced in non-cancer cells, the inhibition of angiogenesis and the blockade of invasion and metastasis. At this point, combined efforts from basic researchers, clinicians and pharmaceutical companies should be made to transfer this knowledge from the labs to the clinics.
Don't miss the next Cannafest conference, 2th - 4th November 2018 in Prague. All lectures are held in Czech or English and are simultaneously translated.
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Does CBD Oil Need THC To Be Beneficial? CBD oil has some benefits, but the real anti-cancer potency comes from Cannabis oil which contains THC. In most states this must be obtained illegally.
Watch the Rick Simpson documentary Run From the Cure on youtube.
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The information in this video is not intended as medical advice.
In addition to searching the Internet for information related cancer and health, please consider consulting with a qualified medical healthcare professional.
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Hi, everyone, I'm Dr. Dan Stein. Our next question is, what medications should not be taken with CBD? Well, one thing that comes to mind has to do with the immune system. Remember, CBD is a potent anti inflammatory, it oftentimes reduces immune system activation. And that can be a problem if you want the immune system to be revved up for a specific reason. In cancer patients being treated with immunotherapies, we want the immune system to be overactive to fight those cancer cells. So using CBD in that setting may be counterproductive. So for now, I think that in general, the recommendation that I give most patients in that situation is hold off on CBD, if you are using immunotherapies for cancer care, and certainly you can ask your oncologist or cancer doctor about what medication specifically they're using and if they depend on the immune system to be over activated. Thanks again, for your questions. Please subscribe, and john and all the folks in United patients group. Thanks again for allowing me to be part of the program.
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