After receiving so many comments and questions at the "Pancreatitis: Facts & Fiction" webinar on April 1st, 2020, Ariel's team decided to assemble a fireside chat with some of our team members to discuss and unpack some of the answers to the most frequently asked questions about pancreatitis!

* Disclaimer * All information regarding pancreatitis and COVID-19 was up to date as of April 1st, 2020. Additional information may become available in the future as more data are gathered and more studies are performed.

Host:
Dr. Mark Haupt, Chief Medical Officer of Ariel Precision Medicine
Speakers:
Prof. David Whitcomb, MD, PhD, Co-Founder of Ariel Precision Medicine
Celeste Shelton, PhD, CGC, Variant Scientist at Ariel Precision Medicine
Katya Orlova, MS, MPH, CGC, Variant Scientist at Ariel Precision Medicine

Topics:
00:00:00 Introduction
00:02:02 What factors are involved in establishing a pancreatitis diagnosis?
00:06:21 Can pancreatitis recur once the gallbladder is removed?
00:07:03 What role do Sphincter of Oddi dysfunction or pancreas divisum play?
00:10:02 What is autoimmune pancreatitis? Are there genetic factors that lead to autoimmune pancreatitis?
00:12:40 What role does fibrosis play in pancreatitis? How does the pancreas atrophy with age?
00:18:52 What role does the development of pancreatitis play in the development of pancreatic cancer (PDAC)?
00:23:39 What kinds of evaluations are available to assess risk of developing pancreatic cancer?
00:29:50 What is maldigestion? What is exocrine pancreatic insufficiency (EPI)? Can it be reversed?
00:35:58 How can the “jar” analogy illustrate complex disease?
00:40:26 Does having a variant involved in a specific disease mean you will get that disease?
00:42:10 How do multifactorial inheritance patterns affect risk for developing complex disease?
00:43:45 What is the role of genetics in hereditary or familial pancreatitis? Is there a difference between the two?
00:48:50 What level of risk does the average person have at age 70? Does family history matter in this context? Have social changes in smoking behavior influenced this change over the past two decades?
00:51:35 What is the relationship between PRSS1 and trypsin? What is trypsin and what role does it play in pancreatitis?
01:01:15 Why should a patient get genetic testing? How does it help? What can it show?
01:05:00 What is the role of CFTR in pancreatitis? If someone has a CFTR variant, does that mean they have cystic fibrosis (CF)? What should happen next if it is found that you have a variant in CFTR?
01:10:49 Are there any variants in CFTR that don’t result in an abnormal sweat chloride test result?
01:13:45 Can you restore the function of the pancreas? What is TPIAT and what role does it play in pancreatitis? What benefit may the procedure have? Who is indicated for the procedure?
01:16:28 What do we know about COVID-19 and the pancreas? Are there any risks specific to pancreatitis patients?
01:24:00 Disclaimer

Contact:
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Pancreatitis acute vs chronic pain, symptoms, location, treatment, diet, diagnosis, pathophysiology for nursing, USMLE, NCLEX, and medical learners!

Learn the difference between acute vs chronic types of pancreatitis, along with common causes including gallstones, alcohol, high triglycerides (fats), and more.

Review of the signs and symptoms of pancreatitis, along with the diagnosis and treatment including diet modifications, gallbladder surgery, and more.

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Timestamps:

00:00 Intro
00:40 What is Pancreatitis?
2:17 Acute vs Chronic Pancreatitis
4:11 Causes of Pancreatitis
5:10 Symptoms of Pancreatitis
6:11 Signs of Pancreatitis
7:01 Diagnosis of Pancreatitis
9:37 Treatment of Pancreatitis
10:44 High-Yield Learning Points

Thanks for watching!

Marie Cook talks about tests that can be used to diagnose children with chronic pancreatitis.

Learn more about pediatric total pancreatectomy and islet auto-transplant (TP-IAT): http://www.uofmchildrenshospit....al.org/Specialties/T

How to detox the pancreas video:
https://youtu.be/q6FmBVuKFYw

Pancreatitis diet video:
https://youtu.be/_xg0AC_WiKk

ACUTE PANCREATITIS: Signs, Symptoms, Causes video:
https://youtu.be/uK2xZrtwLyU

Signs of Poorly Functioning Pancreas #shorts

Symptoms of pancreatic insufficiency
abdominal pain and tenderness.
loss of appetite.
feelings of fullness.
weight loss and diarrhea.


What Are the Symptoms of Your Pancreas Not Working Properly?
Abdominal pain.
Nausea.
Vomiting.
Bloating.
Diarrhea or oily stools.
Fever.
Weight loss.
Malnutrition.

Why is my pancreas not working properly?
In the United States, the most common cause of acute pancreatitis is gallstones. Other causes include chronic alcohol consumption, hereditary conditions, trauma, medications, infections, electrolyte abnormalities, high lipid levels, hormonal abnormalities, or other unknown causes.

What are early warning signs of pancreatic cancer?
Symptoms
Abdominal pain that radiates to your back.
Loss of appetite or unintended weight loss.
Yellowing of your skin and the whites of your eyes (jaundice)
Light-colored stools.
Dark-colored urine.
Itchy skin.
New diagnosis of diabetes or existing diabetes that's becoming more difficult to control.
Blood clots.

What does your poop look like if you have pancreatitis?
When pancreatic disease messes with your organ's ability to properly manufacture those enzymes, your stool looks paler and becomes less dense. You may also notice your poop is oily or greasy. “The toilet water will have a film that looks like oil

Where is the pain of pancreatitis felt?
The main symptom of pancreatitis is pain felt in the upper left side or middle of the abdomen. The pain: May be worse within minutes after eating or drinking at first, more commonly if foods have a high fat content. Becomes constant and more severe, lasting for several days

How do you know if your pancreas is working?
Diagnosis
Blood tests to look for elevated levels of pancreatic enzymes.
Stool tests in chronic pancreatitis to measure levels of fat that could suggest your digestive system isn't absorbing nutrients adequately.
Computerized tomography (CT) scan to look for gallstones and assess the extent of pancreas inflammation.

What does a pancreatic attack feel like?
Acute pancreatitis usually begins with pain in the upper abdomen that may last for a few days. The pain may be severe and may become constant – just in the abdomen – or it may reach to the back and other areas. It may be sudden and intense, or begin as a mild pain that gets worse when food is eaten.

How long does it take for pancreatic cancer to go from Stage 1 to Stage 4?
We estimate that the average T1-stage pancreatic cancer progresses to T4 stage in just over 1 year.

When should I worry about pancreatitis?
The revised version states that the diagnosis has to meet at least 2 of the following criteria: severe, persistent epigastric pain that usually radiates to the back; serum lipase or amylase levels at least 3 times greater than the upper limit of normal.

Is pancreatitis an emergency?
Mild pancreatitis requires short-term hospitalization. Moderate-to-Severe Pancreatitis: Severe pancreatitis can lead to potentially life-threatening complications, including damage to the heart, lungs, and kidneys. Therefore, moderate-to-severe pancreatitis requires more extensive monitoring and supportive care.

Is Pancreatic Insufficiency serious?
EPI is a rare but serious digestive problem. Learn more about what causes it, how to spot the symptoms, and ways you can treat it. EPI is characterized by an inability of the pancreas to produce key digestive enzymes.

What happens when your pancreas is dying?
When this damage is severe, parts of your pancreas may not receive enough blood and oxygen to survive. NP happens when a part of the pancreas or the tissue around it dies from inflammation. The dead part of your pancreas may be separate from the healthy part.

How long can you live with a damaged pancreas?
Your outlook will depend on the condition you have. One study found that the seven-year survival rate after surgery for people with noncancerous conditions like pancreatitis was 76 percent. But for people with pancreatic cancer, the seven-year survival rate was 31 percent.

What causes pancreatic failure?
In the United States, the most common cause of acute pancreatitis is gallstones. Other causes include chronic alcohol consumption, hereditary conditions, trauma, medications, infections, electrolyte abnormalities, high lipid levels, hormonal abnormalities, or other unknown causes.

Can pancreatitis heal itself?
Acute pancreatitis is a self-limiting condition. In most instances, the pancreas heals itself and normal pancreatic functions of digestion and sugar control are restored

How does pancreatitis kill?
If your pancreas becomes inflamed, the enzymes can start to leak into parts of the pancreas instead. These enzymes can sometimes kill pancreatic tissue, resulting in necrotizing pancreatitis.

Symptoms, risk factors and treatments of Hereditary pancreatitis (Medical Condition)

Hereditary pancreatitis is an inflammation of the pancreas, attributed to genetic causes

This video contains general medical information If in doubt, always seek professional medical advice.
The medical information is not advice and should not be treated as such. The medical information is provided without any representations or warranties, express or implied. We do not warrant or represent that the medical information on this websiteis true, accurate, complete, current or non-misleading

Music: 'Undaunted' Kevin Macleod CC-BY-3.0
Source/Images: "Hereditary pancreatitis" CC-BY-2.5 https://www.freebase.com/m/0dst__