Rebecca Epperly, MD, St. Jude Children's Research Hospital, Memphis, TN, discusses the unmet needs of pediatric adrenocortical carcinomas. Within the pediatric cancer population, adrenocortical carcinomas are rare and often harbor TP53 germline mutations. This distinct subset has very poor outcomes despite aggressive multimodal therapies. One of the key challenges are the limited availability of models to investigate pediatric adrenocortical carcinomas preclinically. This interview took place at the American Association for Cancer Research (AACR) Annual Meeting 2023 in Orlando, FL.

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Massimo Terzolo, MD, University of Turin, Turin, Italy, provides an overview of current diagnostic strategies for patients with adrenocortical carcinomas. Approximately a quarter of tumors are discovered serendipitously, and biopsies or surgery performed before diagnostic workup may be dangerous for the patients. Collaboration with endocrinologists is additionally important for successful outcomes. This interview took place at the ESMO Sarcoma and Rare Cancers Congress 2023 in Lugano, Switzerland.

These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.

Your adrenal, or suprarenal, glands are located on the top of each kidney. These glands produce hormones that you can't live without, including sex hormones and cortisol, which helps you respond to stress and has many other functions.
A number of disorders can affect the adrenal glands, including tumors. Tumors can be either benign or malignant. Benign tumors aren't cancer. Malignant ones are. Most adrenal gland tumors are benign. They usually do not cause symptoms and may not require treatment. Malignant adrenal gland cancers are uncommon.
Types of tumors include
• Adrenocortical carcinoma - cancer in the outer part of the gland
• Neuroblastoma, a type of childhood cancer
• Pheochromocytoma - a rare tumor that is usually benign
Symptoms depend on the type of cancer you have. Treatments may include surgery, chemotherapy, or radiation therapy.

Massimo Terzolo, MD, University of Turin, Turin, Italy, discusses management strategies for patients with recurrent adrenocortical carcinoma after surgery. Recurrence is common in this group of patients, where localized therapy in the form of additional surgery and radiotherapy is often used to manage disease. Distant metastasis can further worsen outcomes, but adjuvant therapy may benefit a select number of patients. This interview took place at the ESMO Sarcoma and Rare Cancers Congress 2023 in Lugano, Switzerland.

These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.