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Gastrointestinal stromal tumor (GIST) - Pathology || Easy explaination || MBBS
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• 06/27/23
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GASTROINTESTINAL STROMAL TUMOR (GIST)
• Arise from pacemakers of the GIT known as interstitial cells of Cajal
GIST is the most common mesenchymal tumor of the abdomen
The most common location of the GIST is the stomachº
This is associated with patients having neurofibromatosis 1º.
Microscopically the tumor may show either epithelioid
cells, spindle cells or mixed (both the epithelioid cells and spindle cells).
The useful diagnostic markers are DOG (detected on GIST) and c-kit (CD117)º.
It is best diagnosed withCT scan with PET scan (preferable) or CT scan.
Treatmentis done with surgical resection (localized tumors) and non-excisable tumors are managed with tyrosine kinase inhibitors called imatinib mesylate
Recent Exam Question
Carney's triad is gastric GIST + paraganglioma + pulmonary chondroma.
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