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Amyloidosis Pathogenesis | Signs and Symptoms, Diagnosis and Treatment | Pathology V-Learning
Medical topics are sometimes difficult to understand. Welcome to sqadia.com we are here to guide you through the sea. Today, our discussion will revolve around Amyloidosis.
▬ 📌 Amyloidosis
Amyloidosis can be referred to as a disease characterized by tissue damage due to extracellular protein deposits or amyloids that interfere with normal functioning.
👉 Morphology of Amyloidosis
Protein deposits or amyloids can have two stable shapes:
🟡 Native form
🟡 Beta sheets (which then clump together to form amyloid fibrils).
We will discuss all these reasons ahead so stick around.
▬ 📌 Pathogenesis of Amyloidosis
If we talk about Amyloidosis pathophysiology, Misfolded proteins are cleaved by proteases which sometimes cannot handle the protein burden and misfolded proteins pile up or in some cases, proteins opt such a morphology that is resistant to breakage.
▬ 📌 Types of Amyloidosis
Let’s hover over the types and their mechanisms. Types include:
🔵 AL or primary amyloidosis
🔵 AA or secondary amyloidosis
🔵 Systemic amyloidosis
🔵 Localized amyloidosis
Watch the video for more details.
▬ 📌 Signs and Symptoms of Amyloidosis
Let’s explore about the signs and symptoms which encompass:
⚫️ Kidney (Swelling in face, ankle, and legs)
⚫️ Intestine (Malabsorption and weight loss)
⚫️ Heart (Palpitations)
⚫️ Brain (Memory loss)
▬ 📌 Diagnosis of Amyloidosis
Let us have a glance over the diagnosis of Amyloidosis. Diagnostic tools are:
🟢 Congo Red Stain
🟢 Polarized Light
🟢 Biopsy
▬ 📌 Treatment of Amyloidosis
Treatment of Amyloidosis involves,
🔴 Chemotherapy
🔴 Cardiac Care
🔴 Organ Transplantation
So that was all about an overview of our video on Amyloidosis pathogenesis!
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