Gastrointestinal stromal tumor (GIST) - Pathology || Easy explaination || MBBS

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GASTROINTESTINAL STROMAL TUMOR (GIST)

• Arise from pacemakers of the GIT known as interstitial cells of Cajal

GIST is the most common mesenchymal tumor of the abdomen

The most common location of the GIST is the stomachº

This is associated with patients having neurofibromatosis 1º.

Microscopically the tumor may show either epithelioid

cells, spindle cells or mixed (both the epithelioid cells and spindle cells).

The useful diagnostic markers are DOG (detected on GIST) and c-kit (CD117)º.

It is best diagnosed withCT scan with PET scan (preferable) or CT scan.

Treatmentis done with surgical resection (localized tumors) and non-excisable tumors are managed with tyrosine kinase inhibitors called imatinib mesylate


Recent Exam Question

Carney's triad is gastric GIST + paraganglioma + pulmonary chondroma.