Medical topics are sometimes difficult to understand. Welcome to sqadia.com we are here to guide you through the sea. Today, our discussion will revolve around Amyloidosis.

▬ 📌 Amyloidosis
Amyloidosis can be referred to as a disease characterized by tissue damage due to extracellular protein deposits or amyloids that interfere with normal functioning.

👉 Morphology of Amyloidosis
Protein deposits or amyloids can have two stable shapes:
🟡 Native form
🟡 Beta sheets (which then clump together to form amyloid fibrils).

We will discuss all these reasons ahead so stick around.

▬ 📌 Pathogenesis of Amyloidosis
If we talk about Amyloidosis pathophysiology, Misfolded proteins are cleaved by proteases which sometimes cannot handle the protein burden and misfolded proteins pile up or in some cases, proteins opt such a morphology that is resistant to breakage.

▬ 📌 Types of Amyloidosis
Let’s hover over the types and their mechanisms. Types include:
🔵 AL or primary amyloidosis
🔵 AA or secondary amyloidosis
🔵 Systemic amyloidosis
🔵 Localized amyloidosis

Watch the video for more details.

▬ 📌 Signs and Symptoms of Amyloidosis
Let’s explore about the signs and symptoms which encompass:
⚫️ Kidney (Swelling in face, ankle, and legs)
⚫️ Intestine (Malabsorption and weight loss)
⚫️ Heart (Palpitations)
⚫️ Brain (Memory loss)

▬ 📌 Diagnosis of Amyloidosis
Let us have a glance over the diagnosis of Amyloidosis. Diagnostic tools are:
🟢 Congo Red Stain
🟢 Polarized Light
🟢 Biopsy

▬ 📌 Treatment of Amyloidosis
Treatment of Amyloidosis involves,
🔴 Chemotherapy
🔴 Cardiac Care
🔴 Organ Transplantation

So that was all about an overview of our video on Amyloidosis pathogenesis!

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Dr. Heather Landau is an oncologist and hematologist at the Memorial Sloan Kettering Cancer Center, bone marrow transplant specialist, and director of their Amyloid Program. In this video Dr. Landau reviews the history and goal of treatment for AL amyloidosis. Next she delves into detail and experiences of using high dose therapy and autologous stem cell transplant to treat light chain (AL) amyloidosis. In conclusion, she will discuss how the treatment landscape has changed based on recent advances.

AN UNUSUAL CAUSE OF PERIPHERAL LUNG NODULE - NODULAR PULMONARY AMYLOIDOSIS

Cone Beam CT guided Biopsy

70-year-old female patient, known case of hypertension and well controlled type 2 diabetes mellitus presented with complaints of cough since 2 months. She had unintentional weight loss of 4kgs over the last year. Her symptoms did not improve with symptomatic treatment and inhalers.

HRCT chest performed for further evaluation revealed a 2.1 x 2 cm nodule in right upper lobe, and smaller nodules in the right lower lobe.

Under general anesthesia and lung navigation ventilation protocol ‘Cone Beam Computed Tomography’ was performed. The lesion was identified in the right upper lobe posterior segment and marked. Radial EBUS was performed, but no lesion was identified.

Using 3 dimensional augmented fluoroscopy a 1.1mm mini cryoprobe was placed abutting the lesion. A repeat CBCT spin showed the cryo probe to be in contact with the lesion. Multiple Cryobiopsies were then performed under augmented fluoroscopy and sent for analysis.

Histopathological examination revealed pale, hyalinized, eosinophilic material surrounded by multinucleated giant cells and lymphoplasmacytic cells. This material was found to be congo red positive with apple green birefringence on polarizer.

Final diagnosis: ‘Pulmonary Nodular Amyloidosis’

TAKE HOME MESSAGES

1. CBCT can help confirming tool adjacent to lesion even in instances where radial EBUS doesn't show an image (index case)

2. Primary pulmonary amyloidosis presenting as lung nodules is uncommon and needs to be considered as an uncommon differential of lung nodule

#PulmonaryAmyloidosis #LungNodule #CBCT #Cryobiopsy #RadialEBUS #Histopathology #RareDiseases #MedicalImaging #LungHealth #drvnagarjunamaturu #pulmonologist #YashodaHospitals #hitechcity

콘서트장으로 변신!
#ccm #찬양 #밴드 #팝송 #드라이브 #신나는노래 #청량한노래 #벅차오름 #수련회 #교회


ㅡㅡㅡㅡㅡㅡㅡㅡㅡㅡㅡ
[Playlist]

ALWAYS / Forrest Frank
No Longer Bound / Forrest Frank (feat. Hulvey)
UP! / Forrest Frank, Connor Price
NEVER GET USED TO THIS / Forrest Frank, JVKE
Altar / Hulvey, Forrest Frank
Praise / feat.Brandon Lake, Chris & Chandler Moore

Journey into the incredible story of Shadrach, Meshach, and Abednego! This song brings to life the biblical account of three young men who defied a king's command, choosing unwavering faith over fear. Experience their courage as they face the fiery furnace, trusting completely in God's power—even if it meant the ultimate sacrifice. Their declaration, "But even if He doesn't, we hold Him dear!" echoes through the ages as a testament to true devotion. Discover the miraculous outcome and the powerful lesson of standing firm in your convictions.

Lyrics:

A golden image, reaching to the sky,
King Nebuchadnezzar commanded all draw nigh.
To bow in worship, when the trumpet's sound,
But three young men on sacred ground stood bound.
these three men,
Shadrach, Meshach, and Abednego...
Their hearts held firm, no earthly power swayed,
To any god but theirs, their knees unprayed.
Unbowed, unbent, their faith a burning fire,
Before the flames, their spirits would aspire.
"Our God can save us," their voices rang so clear,
"But even if He doesn't, we hold Him dear!"
these three men,
Shadrach, Meshach, and Abednego...
The whispered words, the king's infuriate stare,
"Another chance, or face the burning snare!"
Seven times hotter, the furnace roared and glowed,
Yet in their stance, a deeper strength was showed.
these three men,
Shadrach, Meshach, and Abednego...
Bound hand and foot, they faced the fiery test,
Their earthly hope surrendered, putting God to the crest.
Unbowed, unbent, their faith a burning fire,
Before the flames, their spirits would aspire.
"Our God can save us," their voices rang so clear,
"But even if He doesn't, we hold Him dear!"
Into the furnace, they were cast below,
But in that heat, a different presence glowed.
A fourth was seen, amidst the burning might,
Like the Son of God, a vision pure and bright.
these three men,
Shadrach, Meshach, and Abednego...
Unbowed, unbent, their faith a living fire,
Through raging flames, their spirits did aspire.
Their God had saved them, His power now revealed,
The king himself in wonderment was healed.
Unbowed... forevermore...
these three men,
Shadrach, Meshach, and Abednego...


© 2025 The Void Choir. All rights reserved.
Lyrics by The Void Choir.
Music generated with Suno.

Hi! Welcome to my channel! ♡ I hope this playlist is a blessing to you as you reflect on God's goodness today! Expect to see more playlists and content on my channel soon. Please subscribe!

about
me~
name: Dailia
age: 23
college: Liberty University
religion: Christian
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