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Gastrointestinal Stromal Tumor (GIST) | Patient Story
Gastrointestinal Stromal Tumor (GIST) | Patient Story administrator 0 Views • 2 years ago

Gastrointestinal Stromal Tumor (GIST)-

Louis Da Silva was 77 when he was told he had a gastrointestinal stromal tumor or GIST. He says what doctors ended up taking out was a cancerous tumor the size of a cantaloupe.

Thankfully, Louis is doing well as he prepares to take the post-surgery maintenance chemo pills. Here is his introductory message. Find his full story at
[a]www.ThePatientStory.com%2Fcancers%2Fgastrointestinal%2Fgist.[/a]

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Background:

The Patient Story turns in-depth interviews from recent cancer survivors into a FAQ format-story along with timelines to give newly diagnosed patients and caregivers a sense of what their lives may look like in the upcoming months. Hear straight from the people who've already been through it.

TPS (formerly OneDavid) was started by Stephanie Chuang, a non-Hodgkin lymphoma survivor, who wants cancer patients and caregivers to get the information they need in a human way, not with medical jargon. Visit www.ThePatientStory.com for more.

If you would like to share a story, give feedback, or just say hello, we'd also love to hear from you! Please write us at support@thepatientstory.com.

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A message from our founder:

My name is Stephanie.

In 2013, I found a story that touched my heart: a group of friends were fighting to raise awareness about bone marrow donations for a young woman who'd been diagnosed with non-Hodgkin lymphoma. It had spread to her brain.

Nina was in dire need of a bone marrow transplant. She's of Asian descent, which narrowed her odds of finding a match (fewer people of the same race and ethnicity registered to donate).

The good news: she found a donor! The wife and mother of two is living happily. I couldn't be happier.
The "odd" news: I was diagnosed with the same cancer, same sub-type just three years later.

That motivated me to create The Patient Story: a company to help cancer patients and caregivers by giving them real answers from real people - people who've actually been through the experience.

Find more at www.thepatientstory.com
Where it all started: https://youtu.be/8VDIjwO9Smg

Gastrointestinal Stromal Tumor (GISTs), Causes, Signs and Symptoms, Diagnosis and Treatment,
Gastrointestinal Stromal Tumor (GISTs), Causes, Signs and Symptoms, Diagnosis and Treatment, administrator 2 Views • 2 years ago

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Chapters

0:00 Introduction
0:54 Symptoms of Gastrointestinal stromal tumors
1:36 Survival rate of Gastrointestinal stromal tumors
2:07 Diagnosis of Gastrointestinal stromal tumors
2:53 Treatment of Gastrointestinal stromal tumors
3:31 Causes of Gastrointestinal stromal tumors




Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. GISTs arise in the smooth muscle pacemaker interstitial cell of Cajal, or similar cells.[2] They are defined as tumors whose behavior is driven by mutations in the KIT gene (85%),[2] PDGFRA gene (10%),[2] or BRAF kinase (rare).[2] 95% of GISTs stain positively for KIT (CD117).[2][3] Most (66%) occur in the stomach and gastric GISTs have a lower malignant potential than tumors found elsewhere in the GI tract.[3]
Classification

GIST was introduced as a diagnostic term in 1983.[2]:1060 Until the late 1990s, many non-epithelial tumors of the gastrointestinal tract were called "gastrointestinal stromal tumors". Histopathologists were unable to specifically distinguish between types we now know to be dissimilar molecularly. Subsequently, CD34, and later CD117 were identified as markers that could distinguish the various types.[citation needed] Additionally, in the absence of specific therapy, the diagnostic categorization had only a limited influence on prognosis and therapy.

The understanding of GIST biology changed significantly with identification of the molecular basis of GIST,[2]:1065 particularly c-KIT. Historically, literature reviews prior to the molecular definition of GIST, and for a short time thereafter, asserted that 70-80% of GISTs were benign.[4][5][6] The identification of a molecular basis for GIST led to the exclusion of many tumors that had been considered as GIST previously, and also the incorporation of a much larger number of tumors that had been labeled as other types of sarcomas and undifferentiated carcinomas.[2]:1065 For example, some previous diagnoses of stomach and small bowel leiomyosarcomas (malignant tumor of smooth muscle) would be reclassified as GISTs on the basis of immunohistochemical staining. All GIST tumors are now considered to have malignant potential, and no GIST tumor can be definitively classified as "benign".[7] Hence, all GISTs are eligible for cancer staging in the AJCC (7th edition) / UICC.[8] Nonetheless, different GISTs have different risk assessments of their tendency to recur or to metastasize, dependent on their site of origin, size, and number of mitotic figures.

Due to the change in definition, clinical pathways of care before the year 2000 are largely uninformative in the current era.[2]
Signs and symptoms
GISTs may present with trouble swallowing, gastrointestinal bleeding, or metastases (mainly in the liver).Intestinal obstruction is rare, due to the tumor's outward pattern of growth. Often, there is a history of vague abdominal pain or discomfort, and the tumor has become rather large by time the diagnosis is made.

My First Cancer Symptom | Ebony's Bladder Cancer Story #shorts
My First Cancer Symptom | Ebony's Bladder Cancer Story #shorts administrator 0 Views • 2 years ago

Ebony is a chemical engineer, mother of 3 and was diagnosed with a muscle-invasive bladder cancer at 45. In "The Bladder Cancer Series," Ebony opens up about her cancer journey, including her first symptoms, how she processed their diagnosis and how she decided on treatment options.

The Bladder Cancer Series:
Episode 1: My Bladder Cancer Story: Treatments, Diagnosis and Finding Support |
https://youtu.be/j51avrScuh8
Episode 2: My Struggle to Get a Bladder Cancer Diagnosis | How I Found Support | https://youtu.be/DVKOjX8JASE
Episode 3: How Cancer Changed My Life | Discovering Intimacy After Treatment | https://youtu.be/dEgvPH9-X2c
Episode 4: "My Doctor didn't Treat Me Well" | How Cancer Research and Advocacy Helped Save My Life | https://youtu.be/N6PeEeWFNUw

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Bladder Cancer Survivor Plays On: A Musician's Life After Treatment
Bladder Cancer Survivor Plays On: A Musician's Life After Treatment administrator 0 Views • 2 years ago

One million guitars — that’s how many Rendal Wall estimates have passed through his hands over a long career first at Gibson Guitar, when it was located in Kalamazoo, Mich., and later at Heritage Guitars. The 76-year-old recently sat down for an interview in the “pickin’ parlor” at Heritage that bears his name. http://michmed.org/1887d

Ren, as he’s known, might as well stand for “Renaissance.” For years, he helped design and deliver custom guitars to top artists — B.B. King, Ted Nugent, Merle Travis. He’s also a talented musician and songwriter in his own right, not to mention an inventor who designed and improved on a variety of guitar parts.

Wall, who recently underwent treatment for stage 2 bladder cancer at the University of Michigan Rogel Cancer Center, was worried side effects would silence the strings around which his life and career have revolved.

Listen to Rendel's story, and hear him talk about and play the music that has been his constant companion before his cancer diagnosis, and after treatment.

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To learn more about the Rogel Cancer Center at Michigan Medicine, visit: https://www.rogelcancercenter.org/

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