The video explains the following key points.
1.Negative Gross margins are all we need. R0= R1, so donot go back to the OR for R1. Lymphadenectomy is not required
2- Understand the indications for adjuvant Gleevec- 3 cm size and greater than 5 mitosis
3- Neoadjuvant Gleevec - Metastatic disease. Unresectable Disease. In unresectable disease start with Gleevec to make it resectable
4- Gleevec MOA: Imatinib mesylate is a protein-tyrosine kinase inhibitor that inhibits the bcr-abl tyrosine kinase, the constitutive abnormal tyrosine kinase
5 Sutent (sunitinib) and Stivarga (regorafenib) are the second and third-line therapies, respectively, for patients that are resistant or intolerant to Gleevec.
#GIST #Absite #surgeryboards

In this video, I describe the technique of removal of Gastrointestinal stroll tumor in the gastric body using double channel endoscope, end loops, snare and anchoring device.

This video covers the basic features of GISTs. We start by understanding the acronym and reviewing the key differences between tumors of connective tissue (sarcomas) and the epithelium (adenocarcinomas). We then review the underlying cell that mutates to become a GIST (the ICC), and what unique features these cells have. Finally, we review staging, treatment, and principles of surgery and discuss how the previously discussed qualities of GISTs are reflected in their management.

These videos are for educational purposes only, do not use to diagnose or treat any disease. This is not clinical advice.

Robin Jones, MBBS, MRCP, MD, The Royal Marsden Hospital, London, UK, explores the evolving treatment landscape for patients with advanced gastrointestinal stromal tumor (GIST), including novel agents in development and the promise of ctDNA in the management of this rare disease. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Annual Congress in Chicago, IL.

These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.

Luigi Boni, MD, FACS, Elisa Cassinotti, MD, Luisa Giavarini, MD, Giulia David, MD, Alessandro Marzorati, MD, Stefano Rausei, MD