Gastrointestinal Stromal Tumor (GIST) of the Stomach

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06/27/23

The video explains the following key points.
1.Negative Gross margins are all we need. R0= R1, so donot go back to the OR for R1. Lymphadenectomy is not required
2- Understand the indications for adjuvant Gleevec- 3 cm size and greater than 5 mitosis
3- Neoadjuvant Gleevec - Metastatic disease. Unresectable Disease. In unresectable disease start with Gleevec to make it resectable
4- Gleevec MOA: Imatinib mesylate is a protein-tyrosine kinase inhibitor that inhibits the bcr-abl tyrosine kinase, the constitutive abnormal tyrosine kinase
5 Sutent (sunitinib) and Stivarga (regorafenib) are the second and third-line therapies, respectively, for patients that are resistant or intolerant to Gleevec.
#GIST #Absite #surgeryboards