Abstract: Gastrointestinal stromal tumors (GISTs) are rare neoplasms that occur predominantly in the stomach or the small intestine. They can result in ulcer-like pain or gastrointestinal bleeding. Although GISTs are submucosal lesions, forceps biopsies are usually normal. Therefore, other ways of obtaining histology should be used, for instance needle-knife biopsies or endoscopic ultrasound-guided biopsies.

The biological behavior depends on location, size, and mitosis activity. In general, GISTs require surgical resection. Patient with high-risk lesions should receive adjuvant chemotherapy with a tyrosine kinase inhibitor. This article is part of an expert video encyclopedia.

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Keywords
Gastrointestinal stromal tumor; Neoplasms; Standard endoscopy; Stomach; Video; Esophagogastroduodenoscopy, Needle-knife keyhole biopsy; gastroduodenoscopy

Rachel has been living with rare, incurable sarcoma for over 20 years. In this video, she shares her story.

After being diagnosed with GIST (gastrointestinal stromal tumours) when she was 15 years old, she immediately went on palliative (comfort) care. She's now 35 years old and has spent the past 20 years living with GIST. She's tried various treatments to help manage her cancer, including getting 90% of her stomach removed.

In 2017, her doctors suggested genome sequencing to better understand her cancer. The results of the test gave her some new insights on treatments, as well as her risk factor for developing two other rare cancers.

She uses her TikTok (@thatgistcancergirl) to spread awareness and share her cancer journey with others.

You can read her story here: https://bit.ly/3u7v4CV

Gastrointestinal Stromal Tumor (GIST) - Histopathology
- mesenchymal tumor
- generally CD117 positive or KIT or PDGFRA mutation-driven
- spindle cells or epithelioid cells or rarely pleomorphic morphology
- CD117+, DOG1+

Slides for the practical part of the pathology exam at Masaryk University

http://atlases.muni.cz/atlases..../stud/atl_en/main+pr

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Gastrointestinal Stromal Tumour is characterized by the formation of aberrant cells in the tissues of the gastrointestinal tract. These tumors are most commonly found in the stomach and small intestine, however, they can be found anywhere in or near the gastrointestinal tract. Small GISTs measuring more than 2 cm but less than 5 cm are routinely treated using laparoscopy, a less intrusive procedure. For tumors larger than 5 cm that can be safely removed, open (or extensive) surgery may be an option. Mrs. Padma Jagini had a GIST in her stomach, which made it difficult for her to carry out her usual activities. Dr. Kiran Peddi, Consultant Medical Gastroenterologist suggested her to undergo a GIST Removal Surgery and successfully removed the tumor. Watch to know more.

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A cancer form called a gastrointestinal stromal tumour (GIST) starts in the digestive system. The stomach and small intestine are where GISTs most frequently develop. A GIST is a cell growth that is hypothesised to develop from a certain kind of nerve cell.

Dr. Anil Kamath
M.S. (General Surgery) (Master of Surgery)
MCh. (Surgical Oncology), DNB (Surgical Oncology)
Senior Consultant Surgical Oncologist

I firmly believe in tailoring the treatment of my patients as per their needs without compromising on the outcomes. The needs of a young lady with breast cancer and no financial constraints is likely to be very different from the needs of an elderly lady coming from a remote village. To understand the needs of the patients we have to have a frank and open hearted discussion with them. I believe that advanced technology like robotic surgery should be used in appropriate cases because when it is used indiscreetly it can cause more harm than good.

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