Presentation for the pediatric neuroradiology virtual congress organized by Hot Topics: https://hot-topics.org/about/

Presentations on recent articles by Pathology Trainees. Special thanks to this month's presenters, Dr. Sameera Rashid, Dr. Veronica Ullici, and Dr. Fouad Zakka.

Link to this month's follow-up quiz and evaluation: https://www.notion.so/July-Ova....ry-Germ-cell-tumors-

This month's articles were:
- Hubbard AK, Poynter JN. Global incidence comparisons and trends in ovarian germ cell tumors by geographic region in girls, adolescents and young women: 1988-2012. *Gynecol Oncol*. 2019;154(3):608-615. doi:10.1016/j.ygyno.2019.06.025
- Heskett MB, Sanborn JZ, Boniface C, et al. Multiregion exome sequencing of ovarian immature teratomas reveals 2N near-diploid genomes, paucity of somatic mutations, and extensive allelic imbalances shared across mature, immature, and disseminated components. *Mod Pathol*. 2020;33(6):1193-1206. doi:10.1038/s41379-019-0446-y
- Snir OL, DeJoseph M, Wong S, Buza N, Hui P. Frequent homozygosity in both mature and immature ovarian teratomas: a shared genetic basis of tumorigenesis. *Mod Pathol*. 2017;30(10):1467-1475. doi:10.1038/modpathol.2017.66

Disclaimer: This video does not constitute medical advice. Always seek the advice of your own physician or other qualified health care professional regarding any medical questions or conditions.

Yolk sac tumors, also known as endodermal sinus tumors, are aggressive germ cell tumors that often arise in young children. On gross pathology, these tumors have a yellow, friable appearance, and hemorrhage is common. On histology under the microscope, Schiller-Duval bodies resembling renal glomeruli may be seen. Labs will reveal an elevated level of alpha-fetoprotein (AFP), as AFP is secreted by yolk sac cells.

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00:00 INTRO
00:12 TRAILER NUMBER ONE
02:40 TRAILER NUMBER TWO
03:20 GERM CELL TUMOURS IN GENERAL
06:03 DYSGERMINOMA
16:13 YOLK SAC TUMOUR
26:50 EMBRYONAL CARCINOMA
35:17 MATURE TERATOMA
43:00 IMMATURE TERATOMA
49:57 MONODERMAL TERATOMA
51:16 THE END


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