Cancer


Research Project Presentation by our research fellow - Harini Balasubramanian on In silico comparative transcriptomic analysis of endemic and epidemic Kaposi’s sarcoma
Project Overview:-
Kaposi’s sarcoma (KS) is a viral neoplasm that manifests as lesions on skin, mucous membranes and inside the body, as well as swelling in the lymph nodes. This study aims to understand the two subtypes of Kaposi’s sarcoma - Endemic and Epidemic. While endemic KS is unequally distributed in broad pockets around the world, the incidence of epidemic or AIDS-related KS overshadows it, since Kaposi’s Sarcoma-****ociated Herpesvirus (KSHV ) seroprevalence ranges from 30-90% in HIV-positive individuals. Early detection of KS with specific mRNA biomarkers could mean a lower mortality rate for People Living With HIV (PLHW). So, this project intends to identify biomarkers and therapeutic targets for early diagnosis and treatment of the disease, using transcriptomic data. The dataset for this project was obtained from the NCBI GEO platform. Exploratory analysis and pre-processing of the data were performed to eliminate outliers. The pre-processed data was further subjected to a differential gene expression analysis followed by Gene Set Enrichment Analysis to identify enriched pathways. 6 differentially expressed genes were identified in each subtype, which have the potential to be used as theranostic targets.
To learn more about her project, please visit: https://learn.omicslogic.com/p....rojects/PiPNZyld6sZg
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Omics Research Symposium- https://edu.omicslogic.com/omi....cs-research-symposiu
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Endemic or African – KS was endemic in all parts of equatorial Africa, particularly in sub-Saharan Africa, prior to the HIV epidemic. Since the onset of the HIV epidemic, the incidence of KS has increased dramatically in those regions
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In this case study, Sanziana Roman, MD, an endocrine surgeon who sees patients with disorders of endocrine systems—including thyroid, parathyroid and adrenal gland—discusses a patient’s treatment for a tumor in the retroperitoneum, near the adrenal gland. In consultation with his endocrinologist, surgery was performed minimally invasively through a unique posterior approach that enabled preservation of the kidney and adrenal gland, and allowed for safe removal of the tumor. For more information on UCSF’s Endocrine Surgery & Oncology Clinic visit https://www.ucsfhealth.org/cli....nics/endocrine_surge


H. Leon Pachter, MD, chair of NYU Langone's Department of Surgery, discusses how the treatment of adrenal tumors requires a multidisciplinary approach, involving endocrinologists, nephrologists, radiologists, pathologists, and surgeons.
The minimally invasive approach to removing adrenal tumors includes making small, keyhole incisions to insert a high-definition camera, which allows surgeons to see better with the camera than they can with the naked eye.
"Patients have much less pain in the recovery period, and as they have much less pain, they recover quickly and can go home much earlier," Dr. Pachter explains.
To make an appointment with an adrenal surgeon, call 212-263-7302.
To learn more about the treatment of adrenal tumors at NYU Langone, visit: http://www.nyulangone.org/loca....tions/adrenal-surger
To learn more about Dr. Pachter, visit: http://www.nyulangone.org/doct....ors/1568492882/h-leo