Cancer

In silico comparative transcriptomic analysis of endemic and epidemic Kaposi’s sarcoma - By Harini
In silico comparative transcriptomic analysis of endemic and epidemic Kaposi’s sarcoma - By Harini administrator 2 Views • 2 years ago

Research Project Presentation by our research fellow - Harini Balasubramanian on In silico comparative transcriptomic analysis of endemic and epidemic Kaposi’s sarcoma

Project Overview:-
Kaposi’s sarcoma (KS) is a viral neoplasm that manifests as lesions on skin, mucous membranes and inside the body, as well as swelling in the lymph nodes. This study aims to understand the two subtypes of Kaposi’s sarcoma - Endemic and Epidemic. While endemic KS is unequally distributed in broad pockets around the world, the incidence of epidemic or AIDS-related KS overshadows it, since Kaposi’s Sarcoma-****ociated Herpesvirus (KSHV ) seroprevalence ranges from 30-90% in HIV-positive individuals. Early detection of KS with specific mRNA biomarkers could mean a lower mortality rate for People Living With HIV (PLHW). So, this project intends to identify biomarkers and therapeutic targets for early diagnosis and treatment of the disease, using transcriptomic data. The dataset for this project was obtained from the NCBI GEO platform. Exploratory analysis and pre-processing of the data were performed to eliminate outliers. The pre-processed data was further subjected to a differential gene expression analysis followed by Gene Set Enrichment Analysis to identify enriched pathways. 6 differentially expressed genes were identified in each subtype, which have the potential to be used as theranostic targets.

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Omics Research Symposium- https://edu.omicslogic.com/omi....cs-research-symposiu

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Kaposi sarcoma ( part 3 ) : Endemic or Lymphadenopathic or African Kaposi sarcoma : USMLE Step 1
Kaposi sarcoma ( part 3 ) : Endemic or Lymphadenopathic or African Kaposi sarcoma : USMLE Step 1 administrator 3 Views • 2 years ago

📌 𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:- https://www.instagram.com/drgbhanuprakash
📌𝗝𝗼𝗶𝗻 𝗢𝘂𝗿 𝗧𝗲𝗹𝗲𝗴𝗿𝗮𝗺 𝗖𝗵𝗮𝗻𝗻𝗲𝗹 𝗛𝗲𝗿𝗲:- https://t.me/bhanuprakashdr
📌𝗦𝘂𝗯𝘀𝗰𝗿𝗶𝗯𝗲 𝗧𝗼 𝗠𝘆 𝗠𝗮𝗶𝗹𝗶𝗻𝗴 𝗟𝗶𝘀𝘁:- https://linktr.ee/DrGBhanuprakash

Endemic or African – KS was endemic in all parts of equatorial Africa, particularly in sub-Saharan Africa, prior to the HIV epidemic. Since the onset of the HIV epidemic, the incidence of KS has increased dramatically in those regions

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Adrenal Gland Disorder: Everything You Need to Know
Adrenal Gland Disorder: Everything You Need to Know administrator 0 Views • 2 years ago

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Chapters

0:00 Introduction
0:45 Types of Adrenal gland disorders
1:28 Causes of Adrenal gland disorders
1:52 Symptoms of Adrenal gland disorders
2:37 Diagnosis of Adrenal gland disorders
3:09 Treatment of Adrenal gland disorders



Adrenal gland disorders (or diseases) are conditions that interfere with the normal functioning of the adrenal glands.[1] Adrenal disorders may cause hyperfunction or hypofunction, and may be congenital or acquired.

The adrenal gland produces hormones that affects growth, development and stress, and also helps to regulate kidney function. There are two parts of the adrenal glands, the adrenal cortex and the adrenal medulla. The adrenal cortex produces mineralocorticoids, which regulate salt and water balance within the body, glucocorticoids (including cortisol) which have a wide number of roles within the body, and androgens, hormones with testosterone-like function.[2] The adrenal medulla produces epinephrine (adrenaline) and norepinephrine (noradrenaline).[2] Disorders of the adrenal gland may affect the production of one or more of these hormones. Adrenal adenoma, a benign tumor of the adrenal gland which may result in overproduction of one or more adrenal hormones, or may be inactive
Adrenocortical carcinoma, cancer of the adrenal cortex
Adrenal incidentaloma, an adrenal tumor (of any type) discovered accidentally during a scan which performed for an unrelated reason
Pheochromocytoma, a catecholamine-producing tumor of the adrenal medulla, which may or may not be cancerous

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