USMLE Hematology and Oncology 21 Oncology and Pharmacology
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https://www.patreon.com/LYMED Welcome to LY Med, where I go over everything you need to know for the USMLE STEP 1, with new videos every day.
Follow along with First Aid, or with my notes which can be found here: https://www.dropbox.com/sh/t5t....fdbhucbanuj9/AADX0mI
Shout out to the reddit user littlebrosencephalon for some of his notes and diagrams used here.
Our last video for our heme and onc block! This video is all on cancer pharmacology, discussing how they work and their side effects.
We start by drawing our cell cycle, seeing where we can manipulate it to stop cancerous cells from proliferating.
Our first drug class is the anti-metabolites, which are drugs that interfere with DNA synthesis. These include drugs such as : 6-MP, cladribine, 6-thioguanin, cytarabine, 5FU, methotrexate and hydroxyurea.
Our next class of drugs include topoisomerase inhibitors, which block the unwinding of DNA during replication. These include: topotecans, and etoposide.
Moving on to anti-cancer antibiotics. These stop bacterial and DNA synthesis and include bleomycin, actinomycin D, and doxorubicin.
Almost done! Next up is microtubule inhibitors, that blocks the formation and division of cells during M phase. These drugs include vinca alkaloids and paclitaxels.
The last drug class is alkylating agents, which bind and crosslink DNA. These drugs are non cell cycle specific and include busulfan, cyclophosphamide, nitrosoureas, and platinum agents like cisplatin.
That's it folks! All done with heme and onc!
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