Leukemia - Causes and Symptoms - Part 1/3
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Leukemia - Causes and Symptoms - Part 1
(0:00-2:08)
Defining Leukemia; proliferative disorders of WBCs; Reactive and Neoplastic types of proliferations.
(2:09-8:50)
Types of Reactive Proliferations; Leukocytosis & Leukemoid reactions.
Types of Neoplastic Proliferations; Leukemia & Lymphoma;
Neutrophilic Leukocytosis, Eosinophilic Leukocytosis, Basophilic Leukocytosis, Lymphocytic Leukocytosis (Lymphocytosis), Monocytosis.
(8:51-17:05)
Leukemoid Reaction; Bone Marrow (BM) pool & Marginated pool of WBCs & their importance in responses under stress.
Differentiating between Leukemoid Reaction & Leukemia; Role of Leukocyte Alkaline Phosphatase (LAP) enzyme & Leukemic Blast Cells.
(17:08-29:30)
Leukemia in detail; & differentiating between Leukemia & Lymphoma;
Hematopoietic Precursor Cells (HPC); role of their malignant transformation in development of either Leukemia or Lymphoma.
Malignant HPCs; diffuse spread in BM & spill over into blood: Leukemia.
Malignant HPCs; discrete, well-defined mass; very small spill into blood, if at all: Lymphoma.
(29:35-31:36)
Overlap/blurring of boundaries b/w Leukemia & Lymphoma; modern perspective.
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