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How to pronounce Ewing sarcoma
How to pronounce Ewing sarcoma in American English or U.S. English.
Ewing sarcoma is a type of cancer that occurs in the bones or in the soft tissue around the bones. Ewing sarcoma most often begins in the leg bones or in the pelvis, but it can occur in any bone. Although Ewing sarcoma is the second most common type of bone cancer in children, it is very rare. Only about 200 children and young adults are found to have Ewing sarcoma each year in the United States. While Ewing sarcoma is more common in children and teenagers, it can occur at any age.
Ewing sarcoma is a classic translocation-associated sarcoma. In other words, Ewing sarcoma is molecularly characterized by the expression of chimeric transcripts generated by specific chromosomal translocations, most commonly involving the fusion of EWS to a member of the ETS family of transcription factors (including FLI1, ERG, ETV1, ETV4, and FEV). Approximately 85% of reported cases of Ewing sarcoma bear an EWS-FLI1 fusion. If your doctor suspects that you have Ewing sarcoma, your cancer cells may be tested to look for changes in the EWSR1 gene, which encodes EWS.
Ewing sarcoma is a terrible disease with an overall survival rate of approximately 50%. Patients with metastatic disease are resistant to treatment, and a proposed explanation for higher rate of treatment failure in metastatic Ewing sarcoma is the presence of additional secondary genomic changes.
How to pronounce Ewing sarcoma. What is Ewing sarcoma. What does Ewing sarcoma mean? Definition of Ewing sarcoma. What does Ewing sarcoma stand for?
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