Cholangiocarcinoma is a type of cancer that originates in the cells lining the bile ducts, which are the tubes that carry bile from the liver to the small intestine. The symptoms, investigations, and treatment of cholangiocarcinoma can vary depending on the location and stage of the cancer.
@DrAshishSachan
Symptoms:
1. Jaundice (yellowing of the skin and eyes)
2. Abdominal pain or discomfort
3. Unexplained weight loss
4. Fatigue
5. Itchy skin
6. Pale stools and dark urine
7. Loss of appetite
8. Fever

Investigations:
1. Imaging tests: These may include abdominal ultrasound, computed tomography (CT) scan, magnetic resonance imaging (MRI), or positron emission tomography (PET) scan to visualize the bile ducts and identify any abnormalities.
2. Endoscopic retrograde cholangiopancreatography (ERCP): This procedure combines endoscopy and X-rays to examine the bile ducts and take tissue samples for biopsy.
3. Biopsy: A sample of tissue is taken from the suspicious area to confirm the diagnosis of cholangiocarcinoma and determine the type and stage of cancer.
4. Blood tests: These may include liver function tests and tumor markers such as CA 19-9.

Treatment:
The treatment options for cholangiocarcinoma depend on the stage and location of the cancer, as well as the overall health of the patient. They may include:
1. Surgery: This is the preferred treatment when possible. It may involve removing part of the bile duct, the gallbladder, and surrounding tissues. In some cases, a liver transplant may be recommended.
2. Radiation therapy: High-energy beams are used to kill cancer cells or shrink tumors. It can be used before surgery to shrink tumors or after surgery to destroy remaining cancer cells.
3. Chemotherapy: Drugs are used to kill cancer cells throughout the body. Chemotherapy may be given before surgery (neoadjuvant), after surgery (adjuvant), or in advanced cases to help control symptoms.
4. Targeted therapy: This involves using drugs that specifically target certain genetic mutations or abnormal proteins in cancer cells.
5. Palliative care: This focuses on managing symptoms and improving the quality of life for patients with advanced cholangiocarcinoma.

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Supraglotic - Hypopharyngeal Malignancy
55 year old male
Presented with stridor
Dynamic airway assessment revealed a mass in supraglottis
Bilateral vocal cord mobile
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Frozen section revealed squamous cell carcinoma
3rd Post Op. Day – Patient can speak and eat
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