Elizabeth Thiele, M.D., Ph.D., director of the Pediatric Epilepsy Program and of the Herscot Center for Tuberous Sclerosis Complex at Massachusetts General Hospital, and professor of Neurology at Harvard Medical School, presents “Tuberous Sclerosis Complex: The Natural History of Epilepsy and Possible Role of Cannabidiol.” This talk was part of "The Fifth Annual Isabelle Rapin Conference on Communication Disorders," held at Albert Einstein College of Medicine. (November 08, 2016)

In this exclusive interview with Karen Keough, MD of Dell Children's Medical Center in Austin, TX, Dr Keough talks about tuberous sclerosis complex (TSC), a genetic disorder that causes non-malignant tumors to form in many different organs, primarily in the brain, eyes, heart, kidney, skin and lungs. Symptoms vary but the ones most commonly associated with TSC are the central symptoms including, seizures, developmental delay, intellectual disability and autism. At present there is no cure for TSC however Afinitor (everolimus) is approved to treat:

Patients with subependymal giant cell astrocytoma (SEGA) associated with TSC who require therapeutic intervention but are not candidates for curative surgical resection
Adults with renal angiomyolipoma and TSC not requiring immediate surgery.

In this virtual event, we welcome Dr Lea Solman (Consultant in Paediatric Dermatology, Great Ormond Street Hospital) to discuss all-things skin-related in the world of Tuberous Sclerosis Complex (TSC), including a Q&A section.

Dr Lisa Henske discusses the importance of lysosomes in TSC. Lysosomes are tiny components that are found inside human cells. They contain digestive enzymes (types of proteins) which break down excess or worn-out parts of the cell, and if a cell is damaged beyond repair, they can help it to self-destruct in a process called programmed cell death, or apoptosis.

Presented as part of the International TSC Research Conference 2021, especially for the TSC community.

Elizabeth Thiele, MD, PhD, pediatric neurologist/epileptologist discusses the different treatment options for patients with epilepsy due to tuberous sclerosis complex.