Learn about the cancer risks associated with an inherited mutation in the MLH1, MSH2, MSH6, PMS2 or EPCAM and the risk-management options for people with an inherited mutation in one of these genes.

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Lynch Syndrome, also known as HNPCC (hereditary nonpolyposis colorectal cancer), is an autosomal dominant disease that is characterized by a mutation in the mismatch repair genes MSH or MLH. This defect in mismatch repair leads to DNA errors at microsatellite regions, which are regions of highly repetitive DNA. The increased error rate at microsatellite regions is termed microsatellite instability, and it is largely responsible for the many cancers seen in Lynch syndrome. Lynch syndrome is most notably characterized by colorectal cancer, which is why it is embodied by the HNPCC acronym: hereditary nonpolyposis "colorectal cancer." It typically occurs in the proximal colon, which helps differentiate it from a similar disease, FAP (familial adenomatous polyposis). Moreover, FAP is characterized by the presence of polyps, whereas HNPCC has relatively much fewer polyps. Again, HNPCC stands for hereditary "nonpolyposis" colorectal cancer. Finally, Lynch patients also exhibit a number of other different cancer types. Notably, endometrial, ovarian, and skin cancers are commonly seen.

Learn about the Lynch syndrome (HNPCC) and other medical school topics with Pixorize's visual mnemonics. Part of our DNA repair playlist for the USMLE Step 1 exam.

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Don Burzen discusses the discovery of his genetic mutation by the NorthShore Center for Individualized Medicine.

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Danielle Burgess has Lynch Syndrome and has overcame colon cancer twice since being first diagnosed at age 17. Here she discusses her experience throughout her treatment. She started Semicolon Stories (http://semicolonstories.com/), and a blog about her experiences with the disease.

LAST WEEK'S VIDEO - Gloria Borges Talks About The Wunder Project and Her Efforts to Find a Cure for Colon Cancer: http://www.youtube.com/watch?v=_qHL2p...

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Disclaimer: This information should not be relied upon as a substitute for personal medical advice, diagnosis or treatment. Use the information provided on this site solely at your own risk. If you have any concerns about your health, please consult with a physician.

People with Lynch syndrome have a higher risk of certain types of cancer, including endometrial, colorectal, and ovarian cancers. Heather Hampel, MS, CGC, Associate Director of the Division of Genetics and Genetic Counseling at City of Hope, will discuss genetic testing, hereditary cancer risk, prevention, and the latest updates for Lynch syndrome care.

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SHARE is dedicated to serving women of all races and cultures, backgrounds and identities. Because no one should have to face breast, ovarian, uterine, cervical or metastatic breast cancer alone.

Kyle Koeppel lost her mother to colon cancer when she was 7, and when Kyle was 19 years old she found out that she had Lynch syndrome. Learn about her experience with the syndrome and how she's taking on the mutation to beat the odds.

LAST WEEK'S VIDEO - Living with Lynch Syndrome: Kyle Koeppel On Her Future
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Disclaimer: This information should not be relied upon as a substitute for personal medical advice, diagnosis or treatment. Use the information provided on this site solely at your own risk. If you have any concerns about your health, please consult with a physician.

Dana-Farber's Matt Yurgelun, MD, discusses Lynch Syndrome research and the challenges of a Lynch Syndrome diagnosis. Dana-Farber's Lynch Syndrome Center offers genetic testing to help identify Lynch Syndrome carriers who may be at increased risk for a variety of cancers. More info: http://ms.spr.ly/6059wc4Zz Video published 3/22/22.

Visit: https://www.dana-farber.org/LynchSyndrome Ramona Lim, MD, a gastroenterologist at Dana-Farber Brigham Cancer Center discusses the importance of regular colonoscopies for individuals with Lynch syndrome, and describes what to expect.