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Heather Hampel, MS, City of Hope, Duarte, CA, gives a summary of Lynch syndrome, the most common form of inherited colorectal cancer and endometrial cancer. The condition also increases the risk of developing other cancers such as biliary and pancreatic cancer, and whilst preventable, is heavily underdiagnosed. Patients who have Lynch syndrome will have annual colonoscopies from their 20s/30s or have an elective hysterectomy. Tumors additionally tend to be microsatellite instability (MSI) high, which can benefit from immune checkpoint inhibitor therapy. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Gastrointestinal Cancers (GI) Symposium in San Francisco, CA.
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Everyone who is diagnosed with bowel cancer in the UK is tested for Lynch syndrome, an inherited cancer pre-disposition syndrome. The same is not true for womb cancer, despite the proportion of womb cancers related to Lynch syndrome being very similar.
Supported by gynaecological cancer charity The Eve Appeal, our academics are making the case that policy need to change, and all endometrial cancers be screened for Lynch syndrome – to improve womb cancer treatments, to increase early diagnoses of womb and bowel cancer, and to help more families prepare for the future.
Help us spread the word by watching and sharing our #LetsTalkLynch films, with new content released on every “Womb Wednesday” of this September’s Cancer Awareness Month.
https://www.policy.manchester.....ac.uk/connect/lynch-
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Learn more about our comprehensive Lynch Syndrome Center at https://www.dana-farber.org/lynchsyndrome
Genetics counselors Fatima Amir, MS, LGC, and Lindsay Kipnis, MS, LGC, in the Division of Cancer Genetics and Prevention at Dana-Farber Cancer Institute, lay out the basics of Lynch syndrome, including cancer risk by mutation, GINA, and current tumor testing practices, at the 2019 LYNKED IN Lynch Syndrome Conference, March 30, 2019.
Everyone who is diagnosed with bowel cancer in the UK is tested for Lynch syndrome, an inherited cancer pre-disposition syndrome. The same is not true for womb cancer, despite the proportion of womb cancers related to Lynch syndrome being very similar.
Supported by gynaecological cancer charity The Eve Appeal, our academics are making the case that policy need to change, and all endometrial cancers be screened for Lynch syndrome – to improve womb cancer treatments, to increase early diagnoses of womb and bowel cancer, and to help more families prepare for the future.
Help us spread the word by watching and sharing our #LetsTalkLynch films, with new content released on every “Womb Wednesday” of this September’s Cancer Awareness Month.
https://www.policy.manchester.....ac.uk/connect/lynch-
The Faculty of Biology, Medicine and Health delivers high quality education and training for health professionals and life scientists. We have a global reputation for research with real-world impact beyond the lab.
Find out more:
https://www.bmh.manchester.ac.uk
https://www.facebook.com/bmhuom/
https://twitter.com/FBMH_UoM
https://www.instagram.com/fbmh_uom/
https://manchesterbmhstudents.wordpress.com/
Dr Stadler presents results at the 2018 American Society of Clinical Oncology (ASCO) Annual Meeting that show people whose tumours have high micro satellite instability (MSI-H) are more likely to have the hereditary condition Lynch syndrome.
She describes how inherited mutations in Lynch syndrome-associated genes were found in 16% of people with MSI-H tumors, compared to 1.9% of those with MSI-I tumors and only 0.3% of those with MSS tumors.
For more on these results, watch her interview with ecancer here, and read our news coverage here.
https://ecancer.org/news/14112.php
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