Air date: April 21, 2021, 3PM
Duration: 00 :59 :34



Description:
Wednesday Afternoon Lecture Series
Advancing Therapies for Children and Adults with Rare Tumors or Genetic Tumor Predisposition Syndromes.

This is the annual G. Burroughs Mider Lecture, established in 1968 in honor of Dr. Mider, the first NIH director of laboratories and clinics, and presented by an NIH intramural scientist to recognize outstanding contributions to biomedical research.

Dr. Widemann is Deputy Director for the NCI Center for Cancer Research, chief of its Pediatric Oncology Branch, and head of the Pharmacology and Experimental Therapeutics Section. Trained as a pediatric oncologist with expertise in drug development, she has applied her expertise to study genetic tumor predisposition syndromes, in particular neurofibromatosis type 1 (NF1) and very rare pediatric and adult solid tumors.

Dr. Widemann will define rare tumors and genetic tumor predisposition syndromes and their unmet medical need. This will be followed by approaches taken in the NIH intramural research program, which provides unique resources to study rare tumors. She will highlight this in examples of NF1, RASopathies, and other rare tumors in children and adults. In addition to providing examples of advances, Dr. Widemann will highlight remaining challenges and future directions. Throughout the talk, she will provide examples how teamwork and collaboration is critical to advance the development of effective therapies for rare tumors.

For more information go to https://oir.nih.gov/wals

Author: Brigitte Widemann, M.D., Chief, Pediatric Oncology Branch, NCI, NIH

Permanent link: https://videocast.nih.gov/watch=41582

Presented at the American Academy of Oral & Maxillofacial Pathology (AAOMP) 2021 Annual Meeting (Virtual), May 2021.

A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: https://kikoxp.com/posts/5084 (dermpath) & https://kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).

Cases:
1. 80 yo man with scar-like plaque on scalp. 
2. 70 yo man with violaceous nodule on nose. History of rhinophyma.
3. 80 yo woman with blue-red ulcerated nodule on scalp.
4. 50 yo woman with periocular mass. Clinical impression: rule out cyst. 
5. 70 yo man with slowly growing periocular mass.
6. 80 yo man with painful ear nodule on antihelix. Clinical impression: rule out squamous cell carcinoma. 
7. 15 yo girl with solitary plaque on scalp.  
8. 25 yo woman with firm nodule on cheek. 
9. 50 yo man with erythematous scaly papule on nose. Clinical impression: wart. 
10. 17 yo boy with nodule on posterior neck. 

Diagnoses (links for digital slides will be added soon): 
1. Desmoplastic melanoma 0:00 (vs spindle cell melanoma 24:14) 
2. Angiosarcoma 09:01
3. Merkel cell carcinoma with squamous cell carcinoma 18:10
4. Extra-nodal Rosai-Dorfman disease ("burnt out" with abundant sclerosis) 28:22
5. Primary cutaneous mucinous carcinoma with in situ component (endocrine mucin producing sweat gland carcinoma precursor) 38:13
6. Chondrodermatitis nodularis helicis (CNH) 46:13
7. Nevus sebaceus 52:57
8. Desmoplastic trichoepithelioma with perineural involvement 1:00:36
9. Trichilemmoma 1:09:47
10. Inverted follicular keratosis IFK 1:13:55

Please check out my Soft Tissue Pathology & Dermatopathology survival guide textbooks: http://bit.ly/2Te2haB ‬

This video is geared towards medical students, pathology or dermatology residents, or practicing pathologists or dermatologists. Of course, this video is for educational purposes only and is not formal medical advice or consultation.

Presented by Jerad M. Gardner, MD. Please subscribe to my channel to be notified of new pathology teaching videos.

Follow me on:
Snapchat: JMGardnerMD
Twitter: @JMGardnerMD
Instagram: @JMGardnerMD
Kiko: https://kikoxp.com/profile/jer....ad_gardner1/content?
Facebook: https://www.facebook.com/JMGardnerMD/

For more information, visit https://ascopubs.org/doi/full/10.1200/JCO.22.01503

Dermpath board review session for my dermatology residents on 5.6.2021. 19 cases in 1.25 hours. Enjoy! (sorry, I don't have digital slides for these cases, but hope to scan and upload them in future)

A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: https://kikoxp.com/posts/5084 (dermpath) & https://kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).

Entities discussed with timestamps: 

Elastofibroma dorsi 0:30
Papillary eccrine adenoma/tubular apocrine adenoma 5:38
Angioinvasive fungal infection (Rhizopus) 10:33
Graphite tattoo (black pigment = exogenous/foreign, not human!) 17:05
Asteroid body 20:55
Flegel's disease (hyperkeratosis lenticularis perstans) 22:19
Oral hairy leukoplakia 25:00
Verruciform xanthoma 28:02
Extramammary Paget disease 31:42
Borderline lepromatous leprosy (Hansen disease) with Fite stain 35:57
AML acute myeloid leukemia (acute myelomonocytic leukemia) 43:33
Necrotizing granulomas (Mycobacteria kansasii) 48:58
Myofibroma 51:26
Tinea nigra 53:30
Ochronosis from topical hydroquinone use 56:07
Mixed tumor with pilomatricoma (or panfolliculoma) component 58:12
Metastatic adenocarcinoma in skin with epidermotropism (lung adenocarcinoma primary site) 1:02:20
Median raphe cyst (2 examples) 1:07:55
Glomus tumor 1:10:56

Other videos and links that may be useful:
Elastofibroma 101 video: https://kikoxp.com/posts/4427 
Microcystic Adnexal Carcinoma (MAC): 5-Minute Pathology Pearls video: https://kikoxp.com/posts/4835 
Microcystic Adnexal Carcinoma vs Desmoplastic Trichoepithelioma (Paisley Tie/Tadpole Pattern) video: https://kikoxp.com/posts/5032 
Angioinvasive fungal infection videos: https://kikoxp.com/posts/4056 & https://kikoxp.com/posts/4923 & https://kikoxp.com/posts/4419 
Awesome pics of asteroid bodies: https://kikoxp.com/posts/5569
Oral hairy leukoplakia 101 video: https://kikoxp.com/posts/4289
"Wart on fire" = verruciform xanthoma tweet (thanks for the tip, @DrPatrickRush!):  https://twitter.com/jmgardnerm....d/status/99103867017


Please check out my Soft Tissue Pathology & Dermatopathology survival guide textbooks: http://bit.ly/2Te2haB ‬

This video is geared towards medical students, pathology or dermatology residents, or practicing pathologists or dermatologists. Of course, this video is for educational purposes only and is not formal medical advice or consultation.

Presented by Jerad M. Gardner, MD. Please subscribe to my channel to be notified of new pathology teaching videos.

Follow me on:
Snapchat: JMGardnerMD
Twitter: @JMGardnerMD
Instagram: @JMGardnerMD
Kiko: https://kikoxp.com/profile/jer....ad_gardner1/content?
Facebook: https://www.facebook.com/JMGardnerMD/