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ANTICANCER DRUGS, ANTINEOPLASTIC DRUGS, MEDICINES USE TO TREAT CANCER,PHARMACOLOGICAL CLASSIFICATION

LEARN IN DETAIL ABOUT CANCER IN PREVIOUS LECTURE ON CANCER
CANCER PART-1 CANCER | PART-1 | TYPES OF CANCER | CLASSIFICATION | ETIOLOGY | EPIDEMIOLOGY | PREVENTION | https://youtu.be/RSJuY05a1-0

CANCER | PART-2 | PATHOGENESIS | CARCINOGEN | ONCOGENES | SIGN & SYMPTOMS | DIAGNOSIS | TREATMENT| https://youtu.be/u4DIq65FLmA

CANCER
Cancer is a term used for diseases in which abnormal cells divide without control & are able to invade other tissues
Cancer cells can spread to other parts of the body through the blood and lymph systems
Also called “Neoplasm”

ANTICANCER DRUGS
These are the class of medication which are use in the treatment of the various type of cancer either benign or malignant
Anticancer Also called Antineoplastic Drugs

Drugs acting directly on cells (Cytotoxic drugs)
Alkylating agents
Nitrogen mustards:
Mechlorethamine
Cyclophosphamide
Ifosfamide
Melphalan
Chlorambucil
Bendamustine

ALKYLATING AGENTS
Ethylenimine
Thio-TEPA
Hexamethylmelamine (altretamine)
Alkyl sulfonates:
Busulfan
Nitrosoureas:
Carmustine, lomustine, streptozocin
Triazines : Procarbazine, dacarbazine, temozolomide

ANTIMETABOLITES
i. Pyrimidine analogs :
5-FU, cytarabine, gemcitabine
ii. Purine analogs:
6-MP, 6-thiogunanine, pentostatin, cladribine
iii. Folic acid analogs (Folate antagonist):
Methotrexate, pemetrexed

Drugs acting directly on cells (Cytotoxic drugs)
NATURAL PRODUCTS AS ANTICANCER
i. Vinca alkaloids:
Vincristine, vinblastine, vinorelbine
ii. Taxanes:
Paclitaxel, docetaxel
iii. Epipodophyllotoxins:
Etoposide, teniposide
iv. Camptothecins:
Topotecan, irinotecan

Antitumor antibiotics use to treat cancer
Anthracyclines antibiotics
Daunorubicin, Doxorubicin,
Epirubicin, Idarubicin, Mitoxantrone
Bleomycin
Dactinomycin
Mitomycin-c

Platinum compounds AS ANTICANCER DRUGS use to treat cancer
Cisplatin
Carboplatin
Oxaliplatin.
Enzymes:
L-asparaginase

Hormones and related agents use to treat cancer
Corticosteroids: Prednisolone, Prednisone
Progestins: Medroxyprogesterone Acetate
Estrogens: Diethylstilbesterol, Ethinyl Estradiol
Androgens: Testosterone
Antiandrogens: Flutamide
GnRH Antagonists (Gonadotropin-releasing hormone (GnRH) ): Cetorelix, Ganirelix, Abarelix
GnRH Analogs: Leuprolide, Goserelin, Nafarelin, Busurelin, Histerelin

ANTIESTROGENS AS ANTICANCER DRUGS use to treat cancer
SERMS (SELECTIVE ESTROGEN RECEPTOR MODULATORS)
Tamoxifen, Doloxifen, Raloxifene
AROMATASE INHIBITORS
Aminoglutethimide
Formestane
Exemestane
Anastrozole
Vorozole & Letrozole

Protein kinase inhibitors use to treat cancer
Tyrosine Kinase, Inhibitors use to treat cancer
Acalabrutinib,
Axitinib,
Crizotinib,
Dasatinib,
Erlotinib,
Gefitinib,
Ibrutinib,
Imatinib,
Lapatinib,
Nilotinib,
Pazopanib,
Ponatinib,
Ruxolitinib,
Sunitinib,
Vandetanib,
Vemurafenib

Pan-kinase Inhibitors use to treat cancer
Everolimus,
Sorafenib,
Temsirolimus

Monoclonal antibodies prescribe to treat various type of cancer
Anti-EGF, EGF-2 Panitumumab, trastuzumab
Anti-CD20/CD30/ CD52 Brentuximab, ofatumumab, rituximab
Anti-CD3/EpCAM Catumaxomab
Anti-PD-1/PD-L1 or CTLA4 Nivolumab, pembrolizumab, atezolizumab, ipilimumab
Anti-VEGF Bevacizumab
VEGF, vascular endothelial growth factor.
EGF, epidermal growth factor
EpCAM, epithelial cell adhesion molecule
CD, cluster of differentiation

MISCELLANEOUS ANTICANCER agents
Retinoids: Isotretinoin
Retinoid X receptor antagonist: Bexarotene
Arsenic compounds: As2O3
Adenosine deaminase inhibitor: Pentostatin
Adrenal cortex suppressant: Mitotane
Substituted urea: Hydroxyurea
Proteasome inhibitor: Bortezomib

#कैंसर की दवाइयों की जानकारी,
कैंसर में कोनसी दवाइया इस्तेमाल होती हे?,
#एंटीकैंसर दवाइया कोनसी हे?,
anticancer drugs classification,
use of anticancer drugs,
list of anticancer drugs,
what are anticancer drugs?
medicine for cancer,

#CANCER,
#ANTICANCERDRUGS,
#ANTINEOPLASTICDRUGS,
#CHEMOTHERAPY,
#antitumor drugs,
#tumor,

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As concerns arise regarding the shortage of cancer treating drugs and the lack of alternatives, Dr. Jen Ashton answers your questions and explains how to navigate this shortage.

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