Joseph Dillon, MB, BCh, BAO, Associate Professor of Endocrinology, Associate Director of the Neuroendocrine Tumor Clinic, University of Iowa

You can support our mission by donating at pheopara.org/donate.

Special thanks to Progenics.

Paraganglioma is a type of neuroendocrine tumor that forms near certain blood vessels and nerves outside of the adrenal glands.

The nerve cells involved in paraganglioma are part of the peripheral nervous system...

So the tumor involves specific nerve cells called chromaffin cells.

Now These tumors can also be called extra-adrenal pheochromocytomas.

Paragangliomas are usually noncancerous (benign).

But some paragangliomas can become cancerous (malignant) and spread (metastasize) to other parts of the body.


Approximately 35-50% of paragangliomas may spread to other parts of the body

Diagnosis & Treatment

You may have following Symptoms :
• High blood pressure
• Fast heartbeat
• Sweating
• Headache
• Shaking or tremors



Generally Doctors use lab tests (Catecholamine Tests ) and imaging tests to diagnose it.


Surgery is the most common treatment.

Other options include radiation therapy, chemotherapy, and targeted therapy.

Alfredo Berruti, MD, University of Brescia, Brescia, Italy, provides a succinct overview of the pathophysiology, comorbidities, and treatment options associated with advanced pheochromocytoma and paraganglioma. Prof. Berruti also stresses the necessity to improve on the targeted therapies currently at our disposal now that these tumors have been successfully divided into three molecular subtypes; pseudohypoxia, kinase-signaling, and Wnt altered. This interview took place at the ESMO Sarcoma and Rare Cancers Congress 2023 in Lugano, Switzerland.

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Presented by Justin Annes, MD, PhD
Endocrine Oncology Cancer Care Program, Head of PPGL Program
Assistant Professor of Medicine, Division of Endocrinology, Stanford University

You can support our mission by donating at pheopara.org/donate.

Special thanks to Progenics.

Los feocromocitomas y paragangliomas son tumores neuroendocrinos. Estos tumores pueden segregar hormonas, en ocasiones como respuesta a alimentos, esfuerzo físico...
Son de obligado estudio en hipertensión refractaria, en jóvenes.

#feocromocitoma #paraganglioma #catecolaminas #tumorneuroendocrino

Roderick Clifton-Bligh, BSC MB BS FRACP PhD FFSc
Head of Department of Endocrinology, Royal North Shore Hospital, Conjoint Associate Professor in Medicine, University of Sydney

You can support our mission by donating at pheopara.org/donate.

Special thanks to Progenics.