Multiple Endocrine Neoplasia Type 2


This video discusses the three most common MEN syndromes (MEN 1, MEN2A, MEN2B) by providing useful mnemonics as well as a brief explanation of commonly associated tumors (e.g., pheochromocytoma, medullary thyroid carcinoma).
This individual GI lecture video has been clipped directly from the comprehensive GI lecture series videos and may therefore contain errors associated with this process. You can find the “GI Lecture Series” playlist on the channel to watch the full lecture videos in their entirety.
Studying for board examinations can be daunting, with every resource offering a unique take on each medical condition. I created this channel to provide medical students - especially those studying for USMLE Step 1 and COMLEX Level 1 - with a "one-stop-shop" for medical content. For each lecture, I synthesized information from almost every major medical resource to provide you with a comprehensive and integrated lesson plan. I emphasize the pathophysiology of each disease so that you can leave each lecture with a detailed understanding of the material instead of memorizing hundreds of random facts.
All content discussed within the lecture series is designed for educational purposes only and should not substitute clinical judgment.
Original material in this lecture series may be redistributed provided that proper attribution is utilized. Please use “https://www.youtube.com/@doc.smoove” when attributing source material.
Errata:
Timestamps:
0:00 Overview
1:36 MEN1
2:33 MEN2A
5:57 MEN2B


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Patient quality of life and prognosis in multiple endocrine neoplasia type 2
by Grey, J., Winter, K. via Endocrine Related Cancer current issue
Multiple endocrine neoplasia type 2 (MEN2) refers to the autosomal-dominant neuroendocrine tumour syndromes, MEN type 2A (MEN2A) and MEN type 2B (MEN2B). They are typified by the development of medullary thyroid cancer (MTC), phaeochromocytoma and parathyroid hyperplasia in MEN2A and MTC, phaeochromocytomas, ganglioneuromatosis and skeletal abnormalities in MEN2B. The aggressiveness of MTC is variable according to genotype, and although it is still the major cause of mortality in both conditions, prognosis has improved dramatically in those diagnosed and treated at a young age thanks to predictive genetic testing. Nevertheless, metastatic MTC, ganglioneuromatosis and a variety of other negative clinical and psychosocial impacts on quality of life and/or prognosis in MEN2 persist. In the absence, at the time of writing, of any large-scale research into quality of life specifically in MEN2, this review includes data from patient surveys and anonymised patient anecdotes from the records of the Association for Multiple Endocrine Neoplasia Disorders (AMEND), for whom the authors work. We recommend that these patients are cared for only in centres of expertise able to provide expert diagnosis, treatment and continuity of care, including psychological and transition support. Only in this way can the clinical advances of the last two and half decades be built upon further to ensure that the care of these complex, lifelong patients can be considered truly holistic.
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This video discusses the three most common MEN syndromes (MEN 1, MEN2A, MEN2B) by providing useful mnemonics as well as a brief explanation of commonly associated tumors (e.g., pheochromocytoma, medullary thyroid carcinoma).
This individual GI lecture video has been clipped directly from the comprehensive GI lecture series videos and may therefore contain errors associated with this process. You can find the “GI Lecture Series” playlist on the channel to watch the full lecture videos in their entirety.
Studying for board examinations can be daunting, with every resource offering a unique take on each medical condition. I created this channel to provide medical students - especially those studying for USMLE Step 1 and COMLEX Level 1 - with a "one-stop-shop" for medical content. For each lecture, I synthesized information from almost every major medical resource to provide you with a comprehensive and integrated lesson plan. I emphasize the pathophysiology of each disease so that you can leave each lecture with a detailed understanding of the material instead of memorizing hundreds of random facts.
All content discussed within the lecture series is designed for educational purposes only and should not substitute clinical judgment.
Original material in this lecture series may be redistributed provided that proper attribution is utilized. Please use “https://www.youtube.com/@doc.smoove” when attributing source material.
Errata:
Timestamps:
0:00 Overview
1:36 MEN1
2:33 MEN2A
5:57 MEN2B


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