Multiple endocrine neoplasm with Ginger Bread Men
Multiple endocrine neoplasias (MEN) are genetic conditions that result in tumours in many different endocrine organs in the body.
MEN1 result from mutation of a tumour suppressor gene on chromosome 11. Individuals with MEN1 can have pituitary tumours, hyper-parathyroidism, bronchial and thymic carcinoids, cutaneous lesions such as lipomas, pancreatic neuroendocrine tumours (non-functional), and adrenal tumours.
MEN2a and 2b result from gain-of-function mutation of the RET proto-oncogene on chromosome 10. Individuals with MEN2a can have hyper-parathyroidism, medullary thyroid carcinoma and pheochromocytoma. Individuals with MEN2b can have all the features that people with MEN2a have, but in addition, they can also have Marfanoid habitus, skeletal abnormalities such as craniosynostosis, dental enamel abnormalities, and multiple mucosal neuromas.
Special thanks to my brother for the filming and cookie cutter, and Carolyn for the milo!
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