Lisa Giulino Roth, MD, assistant professor of Pediatrics in Medicine, Joan and Sanford I. Weill Department of Medicine , Weill Cornell Medicine/NewYork-Presbyterian Hospital, discusses treating adolescent and young adult patients with Hodgkin lymphoma.

Dr. John Hainsworth of the Sarah Cannon Research Institute explains the different types of non-Hodgkin's lymphoma.

Hodgkins lymphoma is a neoplasm of the immune system that is marked by the presence of a type of cell called the Reed-Sternberg cell.

The two major types of Hodgkin lymphoma are classical Hodgkin lymphoma and nodular lymphocyte-predominant Hodgkin lymphoma.

Classic Hodgkin lymphoma
Classic Hodgkin lymphoma (cHL) accounts for more than 9 in 10 cases of Hodgkin
lymphoma in developed countries.
The cancer cells in cHL are called Reed-Sternberg cells. These cells are usually an
abnormal type of B lymphocyte. Enlarged lymph nodes in people with cHL usually have
a small number of Reed-Sternberg cells with a lot of normal immune cells around them.
These other immune cells cause most of the swelling in the lymph nodes.
Classic HL has 4 subtypes:

nodular sclerosis Hodgkin lymphoma or NSCHL: This is the most common type
of Hodgkin disease in developed countries. It accounts for about 7 out of 10 cases.
It's most common in teens and young adults, but it can occur in people of any age.
It tends to start in lymph nodes in the neck or chest.

Mixed cellularity Hodgkin lymphoma or MCCHL: This is the second most
common type, found in about 4 out 10 cases. It's seen mostly in people with HIV
infection. It's also found in children or the elderly . It can start in any lymph node but
most often occurs in the upper half of the body.

Lymphocyte-rich Hodgkin lymphoma: This sub-type isn't common. It usually
occurs in the upper half of the body and is rarely found in more than a few lymph
nodes.

Lymphocyte-depleted Hodgkin lymphoma: This is a rare form of Hodgkin
disease. It's seen mainly in older people and those with HIV infection. It's more
aggressive than other types of HL and likely to be advanced when first found. It's
most often in lymph nodes in the abdomen (belly) as well as in the spleen, liver, and
bone marrow.

Nodular lymphocyte-predominant Hodgkin lymphoma
Nodular lymphocyte-predominant Hodgkin lymphoma accounts for about 5%
of cases. The cancer cells in NLPHL are large cells called popcorn cells (because they
look like popcorn), which are variants of Reed-Sternberg cells. You may also hear these
cells called lymphocytic and histiocytic (L&H) cells.
NLPHL usually starts in lymph nodes in the neck and under the arm. It can occur in
people of any age, and is more common in men than in women. This type of HL tends
to grow more slowly and is treated differently from the classic types.
Symptoms include the painless enlargement of lymph nodes, spleen, or other immune tissue. Other symptoms include fever, weight loss, fatigue, or night sweats. Also called Hodgkin disease.

Francesco Maura, MD, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, outlines the findings of the first study to perform whole-genome sequencing (WGS) to examine the genomic landscape of Hodgkin lymphoma (HL) in adult and pediatric patients. Dr Maura explains that previous studies used whole-exome sequencing (WES) and targeted sequencing, which do not allow identifying copy number variants, structural variants or mutational signatures. The study showed that there are several different drivers shaping the behaviour and pathogenesis of HL. Additionally, the study was able to reconstruct the chronological order of events and show the absolute time at which a chromosomal gain occurred in a selected patient. The study also revealed that pathogenesis takes place over several years, which underlines the importance of understanding the mechanisms that occur during this time in order to prevent the disease from appearing in the first place. This interview took place at the 63rd ASH Annual Meeting and Exposition congress in Atlanta, GA.

thanks for watching ♥

- i think i forgot to say i had major joint/bone pain starting in June or July ‘22. felt like my legs were going to break..
- the doctor who helped me find my diagnosis was Dr. Rosenburg Reyes at 25 Again in Louisville, Kentucky!

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