Leukemia - Acute Myeloid - AML - Childhood

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Leukemia - Acute Myeloid - AML - Childhood

CAR T-cell Therapy: Acute Lymphoblastic Leukemia - A Drive through the Past, Present and Future administrator 2 Views • 2 years ago

This is a recording of a workshop that took place at the 2023 Survivorship Symposium.

Summary: This video will discuss why a patient with acute lymphoblastic leukemia (ALL) may need CAR T-cell therapy; the steps involved in making a CAR T-cell product; how CAR T-cells are administered to patients; and both short- and long-term side effects, and outcomes associated with CAR T-cell therapy.

Presenter: Haneen Shalabi DO, National Institutes of Health, Pediatric Oncology Branch

To read the transcript, go to:
https://www.bmtinfonet.org/vid....eo/car-t-cell-therap

Highlights:

Childhood acute lymphoblastic leukemia (ALL) is the most commonly diagnosed cancer in children. In the United States, there are about 30 cases per million in children below the age of 20. It accounts for about 25% of all new pediatric cancer diagnoses.
Acute Lymphoblastic Leukemia (ALL) in adults is a more rare diagnosis. It is, however, still the second most commonly diagnosed acute leukemia in aduls. There are about 6,500 cases/year in the United States. Only 40-50% of adults diagnosed with ALL will achieve long-term, durable remissions.with standard therapy.
CAR T-cell therapy is a new form of treatment that may cure, or prolong the life, of patients who do not respond to standard chemotherapy or a bone marrow transplant.

April 2023, Part of the Virtual Celebrating a Second Chance at Life Survivorship Symposium

Presentation is 58 minutes long including 13 minutes of Q & A.

Key Points:

(01:26): Why people may need CAR T-cell therapy for leukemia; the steps involved in making a CAR T-cell product; some of the short and long-term side effects associated with CAR T-cell therapy; and results following CAR T-cell therapy.

(04:22): 85 to 90% of patients diagnosed with leukemia will be cured of their disease with standard of care chemotherapy.

(05:24): Based on decades of research, survival for pediatric leukemia patients has improved. This is, in part, due to using multi-drug chemotherapy as well as giving intrathecal chemotherapies to prevent leukemia from attacking the central nervous system.

(10:22) . Healthy T-cells in the body fight infection and/or foreign objects in our bodies. Chimeric antigen receptor T-cell therapy converts normal T-cells, collected from a patient’s own body, into T-cells that can recognize cancerous cells..

(13:08): Making a CAR T-cell involves several steps, the first of which is apheresis. A patient is hooked up to a special machine that extracts the patient's blood, separates out white blood cells, including T-cells, and returns the rest of the blood product to the patient.

(14:05): The T-cells are then sent to a special laboratory where they are converted in to CAR T-cells. Prior to infusing the CAR T-cells into patients, the patient typically receives some chemotherapy to prepare the body for the CAR T-cells.

(23:37): In addition to CAR T-cell products that are currently approved by the Federal Drug Administration (FDA), there are clinical trials a patient may participate in test non-FDA approved CAR T-cell products. Information about these trials can be found online at clinicaltrials.gov.

(28:04): Cytokine Release Syndrome (CRS), is the most common side effect from CAR T-cell therapy. Over 80% of patients who receive CAR T-cells will get CRS, with such symptoms as fever, low blood pressure and/or shortness of breath.

(33:40): 30-87% of patients who receive CAR T-cells experience some degree of neurologic side effects.

(42:18): Research is onging into how CAR T-cell therapy psychosocially affects patients; how to reduce toxicities; and ways to improve survival after CAR T-cell therapy.

Meet the speaker: https://ccr.cancer.gov/staff-d....irectory/haneen-shal

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administrator 0 Views • 2 years ago

"Nutrition for Leukemia Patients: Best Foods to Eat for Managing Symptoms"
Leukemia is a type of cancer that affects the blood and bone marrow, and it can weaken the immune system and cause fatigue and other symptoms. While there is no specific diet that can cure leukemia, eating a healthy, balanced diet can help patients manage their symptoms and maintain their strength during treatment. In this article, we will explore the best foods to eat if you have leukemia, including foods that are high in protein, iron, and other nutrients that can help support immune function and promote healing. We will also discuss the importance of hydration and ways to manage common side effects of leukemia treatment, such as nausea and loss of appetite. Whether you're a leukemia patient or a caregiver looking for ways to support your loved one's nutrition, read on to discover the foods that can help you manage symptoms and promote better health during leukemia treatment.

WATCH 🎥: 6 Foods That Are Bad For Stress And Anxiety:-
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Music: https://www.youtube.com/watch?v=6GHrk...
Summary:
Diet is a weapon for any health issue, even leukemia. It’s important for the patient to eat healthily. However food is not a treatment, but it’s helpful in controlling and avoiding diseases. Saying that, let’s get started with our content.

To boost the healing power, the habit that leukemia patients should adopt is, eat frequently every day.

Eat less but eat frequently. Consuming a small meal every hour or so ensures that nutrients are being supplied to brace medication.

A healthy diet may minimize the side effects of treatment and boost the probability of recovery.

Leukemia patients must eat at least 5 to 6 times a day. If possible, it would be much better to provide something healthy every following hour.

So what can you provide to a person suffering from leukemia?

Get protein-rich food

Protein is a vital nutrient for the formation of cells and tissue in the body. Plus, protein aids in repairing damaged cells. So, it’s important for leukemia patients to take adequate protein for faster recovery.

Including chicken or fish in the diet plan can help in fighting cancer cells. Patients may get bored eating the same every day, try incorporating chicken and fish in the dishes. If possible, provide a variety of protein-rich food with the permission of the doctor.

Choose Whole grain over regular grain
Every food person with leukemia eats should count. Each bite must provide nutrients to the patient as far as possible.

For this reason, he or she has to eat a good percentage of whole grain. Go for whole-wheat bread, whole-grain cereal, and brown rice instead of white rice.

Whole grains are fiber-rich food that promotes digestion, healthy lipids, and healthy gut microbiota.

But for some leukemia patients, a high fiber diet can worsen nausea. So take the doctor’s suggestion before making even the smallest change in the diet.

Enough Fresh Fruits

A diet with a good ratio of fresh fruits is necessary for leukemia patients. Don’t get canned or frozen fruits. They won’t aid as much as fresh fruits.

When buying fruits, you can get blueberries, oranges, apples, pomegranates, or any preferable fruits of the patient.

They contain vitamins and minerals that may slow tumor growth, helping patients to recover.

Sufficient Vegetables

Vegetables are another great food that can support leukemia medication. Rich in numerous nutrients, vegetables should be occupying a large part of the diet.

Actually, fruits and vegetables combined can make a good portion in the diet plan.

Choose veggies which are recommended by the doctor and preferred by the patient. The one thing that you need to be careful about is, you give him or her fresh veggies.

To supply sufficient nutrients to the patient’s body, you can steam vegetables. And find ways to add more veggies to the plate.

Make vegetable soup, salad, or juice. If you know any other dish with vegetables, then you may incorporate it into the diet too.

For more information, please watch the video until the very end.
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