UCLA pediatric hematologist and oncologist Satiro De Oliveira, MD and executive director of Greater Los Angeles, LLS, Shannon Sullivan discuss childhood leukemia and lymphoma. Our specialists look at the emergence of new strategies for treating these cancers in the pediatric population, in a conversation moderated by Leila Evangelista from the Leukemia & Lymphoma Society. Learn more about our Closer to a Cure series: https://www.uclahealth.org/closer-to-a-cure

Authors: Pinli Zou, Min Zhou, Jinquan Wen, Xin Liao, Yali Shen, Haiyan Liu, Lin Song, Jianwen Xiao

Acute lymphoblastic leukemia is the most common cancer in children, and precursor B-cell acute lymphoblastic leukemia accounts for approximately 75-80% of newly diagnosed pediatric ALL cases. Previous studies have shown that fusion genes are the most important cause of pediatric B-cell acute lymphoblastic leukemia, and the prognosis of different fusion genes is significantly different. Specific fusion genes play important roles as risk factors for strategic treatment. However, not all patients are positive for fusion genes. Therefore, we tried to assess the outcomes of and risk factors for pediatric B-cell acute lymphoblastic leukemia without specific fusion genes in three Chinese institutes, and then we used the next generation sequencing in relapsed patients to try to reveal more risk gene mutations in pediatric B-cell acute lymphoblastic leukemia.

DOI: https://doi.org/10.17305/bjbms.2021.5879

The BJBMS is а premier venue for discoveries in basic and clinical biomedical science. It was founded in 1998 and is published by the Association of Basic Medical Sciences, a nonprofit honor organization of physician-scientists.

Broad readership and scope - The BJBMS reaches readers across a wide range of medical disciplines and sectors. The journal publishes basic and translational/clinical research submissions and reviews in all biomedical specialties, including Genetics and Molecular biology, Immunology, Microbiology, Pathology, Biochemistry, Pharmacology, Anatomy, Biomaterials, new and emerging research and diagnostic methods, new and emerging medical entities, and others.

Open access - All research is available to the public for free. The BJBMS deposits published articles in PubMed Central, which satisfies the NIH Public Access Policy and other similar funding agency requirements.

Indexing and abstracting - SCIE, JCR, PubMed/MEDLINE, PubMed Central (PMC), SCOPUS, DOAJ, EBSCO, PROQUEST, Dimensions, Google Scholar, EMBASE/Excerpta Medica, Europe PubMed Central, Medscape, ROAD, HINARI, CAS, many libraries.

You can visit us at:
Website - https://www.bjbms.org
Twitter - https://twitter.com/bjbms
LinkedIn - https://www.linkedin.com/company/bosn...
Facebook - https://www.facebook.com/bjbms.org/

Visit http://www.ecancer.org for moe

Prof Moorman (Newcastle University, Newcastle, UK) talks to ecancertv at EHA 2015 about the importance of identifying biomarkers for childhood relapsed acute lymphoblastic leukaemia (ALL).

A common side effect of a bone marrow transplant is loss of fertility, in both men and women. For women, treatment can also result in early menopause. This is due to the use of radiotherapy and high doses of chemotherapy used during treatment.1

In this video, Jonjo, Kelly, Linda and Mark discuss the emotional impact of learning they would be unlikely to have children following their transplant treatment - as well dealing with other hormonal changes and the impact it had on their personal relationships.

Each video in this series covers a different chapter in the journey of receiving a bone marrow transplant, a treatment option for some adults diagnosed with acute lymphoblastic leukaemia (ALL).2

Whilst every cancer patient's experience is different, this video series hopes to give an insight into real stories, offer some practical advice and give support to anyone who has received a cancer diagnosis. However, individuals should always speak to their doctor or healthcare team when making any treatment decisions.

Acute lymphoblastic leukaemia is a rare form of blood cancer that starts from white blood cells in the bone marrow. Although the majority of cases of ALL are diagnosed in younger people, it can also develop in adults.3

For more information and support, visit https://www.nhs.uk/conditions/....acute-lymphoblastic-

PP-UNP-GBR-3288 / January 2023
1. https://www.cancerresearchuk.o....rg/about-cancer/canc
2. https://www.cancerresearchuk.o....rg/about-cancer/acut
3. https://www.nhs.uk/conditions/....acute-lymphoblastic-

Our latest research shows that within the next decade, we can make acute lymphoblastic leukaemia (ALL) preventable. Your support will help us make this disease a thing of the past. Donate today: https://www.icr.ac.uk/ALL


Stock footage provided by Videvo, downloaded from https://www.videvo.net

Video on etiology, pathology, clinical features and treatment of acute lymphoblastic leukemia / ALL in pediatrics

Hematology Playlist : https://www.youtube.com/playli....st?list=PLLywMQWaFPR

For the ppt/pdf, check out my patreon page: https://www.patreon.com/indianmedico

"At that point, the doctors and also me were like, 'How is it possible from a cough that she broke four vertebrae?'"

When 8-year-old Isabella began complaining of pain in her legs and back, her mother Paola took her to see the GP. However, it wasn’t until over a month later that doctors finally discovered Isabella’s symptoms, including four broken vertebrae, were due to acute lymphoblastic leukaemia (ALL).

Here, Paola recounts her daughter’s #SpotLeukaemia story http://bit.ly/PaolaIsabellaHopwood