B cell acute lymphoblastic leukemia without specific fusion genes, VIDEO ABSTRACT
Authors: Pinli Zou, Min Zhou, Jinquan Wen, Xin Liao, Yali Shen, Haiyan Liu, Lin Song, Jianwen Xiao
Acute lymphoblastic leukemia is the most common cancer in children, and precursor B-cell acute lymphoblastic leukemia accounts for approximately 75-80% of newly diagnosed pediatric ALL cases. Previous studies have shown that fusion genes are the most important cause of pediatric B-cell acute lymphoblastic leukemia, and the prognosis of different fusion genes is significantly different. Specific fusion genes play important roles as risk factors for strategic treatment. However, not all patients are positive for fusion genes. Therefore, we tried to assess the outcomes of and risk factors for pediatric B-cell acute lymphoblastic leukemia without specific fusion genes in three Chinese institutes, and then we used the next generation sequencing in relapsed patients to try to reveal more risk gene mutations in pediatric B-cell acute lymphoblastic leukemia.
DOI: https://doi.org/10.17305/bjbms.2021.5879
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