Adenoid cystic carcinoma (ACC) is an uncommon form of malignant neoplasm that arises within secretory glands, most commonly the major and minor salivary glands of the head and neck. Other sites of origin include the trachea, lacrimal gland, breast, skin, and vulva. This neoplasm is defined by its distinctive histologic appearance.
Adenoid cystic carcinoma is a slow growing and relentless salivary gland malignancy composed of epithelial and myoepithelial neoplastic cells that form various patterns, including tubular, cribriform , and solid forms

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Hello my name is Alexander Damron. I received my medical degree from the Medical University of South Carolina and subsequently completed my residency training in Anatomic and Clinical Pathology at Baylor College of Medicine followed by a 1year Multi-Disciplinary Breast Pathology Fellowship at the University of Pennsylvania.

This video is the second video on my channel to highlight interesting cases in breast pathology! Please leave any comments below and I will do my best to answer!

Disclaimers: I have permission from ExpertPath to use images from their website in these presentations. I have no proprietary gain from these videos, and they serve simply as an educational resource.

I hope you find the video helpful and enjoy the case!

-Alexander Damron, M.D.

#BreastPathology #BreastPath #Pathology

Adenoid cystic carcinoma, cylindroma ,adenocystic carcinoma ,adenocystic basal cell carcinoma ,pseudo-adenomatous basal cell carcinoma ,basaloid mixed tumour ,fifth most common ,clinical features ,histological features ,cribriform ,tubular ,solid ,swiss cheese or honey comb ,treatment ,and prognosis

Professor Arturo Sala of Brunel University talking at our October 2021 gathering.

This is a general overview of one H&E slide containing primary breast adenoid cystic carcinoma (AdCC), a rare carcinoma of the breast, with information on demographics, immunohistochemistry (IHC) and special stains, and genetic/molecular findings associated with these lesions.

Please let me know in the comments if you have any suggestions for improvements, topics you found confusing, or things that you think may be interesting to have a review on.

CLARIFICATION: Overall, AdCC has an excellent prognosis, and can even be cured in many patients with the treatment options described. The 20% increased survival benefit mentioned in the video is with use of radiation. Even without radiation post-surgery, approximately 86% of patients will survive 10 years post-diagnosis.

Demographics: 00:00 / 00:19
Histology and Differentials: 00:45
IHC and Specials: 05:14
Genetics and Molecular: 08:02
Treatment and Prognosis: 09:45

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