What is Lynch Syndrome?
Lynch Syndrome, also called hereditary non-polyposis colorectal cancer, is the most common cause of inherited colorectal cancer. Colorectal cancer is the second leading cause of cancer-related death in the United States.
Symptoms of Lynch Syndrome include: abdominal pain, bloody stool and a change in bowel habit patterns.
The lifetime risk of colorectal cancer for Lynch Syndrome varies but can be has high as 47 percent. Colorectal cancer in Lynch Syndrome tends to occur at a younger age (45-60) compared to sporadic colon cancer (69).
While colorectal cancer is the most common, other cancers associated with Lynch Syndrome include: uterine, ovarian, stomach, small bowel, bile duct, ureter, brain, sweat gland tumors.
How is Lynch Syndrome diagnosed?
Different strategies for identifying individuals at risk for Lynch Syndrome consider family history, prediction models, tumor-based testing and genetic analysis. Another commonly used strategy to diagnose Lynch Syndrome is simplified into the "3-2-1 rule". The "3-2-1 rule" means patients at risk for Lynch Syndrome will have: three or more relatives with Lynch Syndrome related cancers, two generations affected by Lynch Syndrome related cancers, and one or more of those cases of cancer were diagnosed before the age of 50.
If you have a family history that includes Lynch Syndrome related cancers, testing should be considered.
If you have questions about your gastrointestinal health and how hereditary conditions may play a part in your overall health, contact the gastroenterologists at Granite Peaks Gastroenterology.
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