What is Large Granular Lymphocytic Leukemia (LGLL)?
My name is Dr. Shauna Collins and I have cancer. I happen to be a medical doctor as well. I have a very rare leukemia called: Large Granular Lymphocytic Leukemia (LGLL). Most of my LGLL videos are extremely candid and very, very personal. They document my personal cancer journey - the good, the bad and the ugly. I also explain how I've addressed this cancer with nutrition and juicing with some (but not all) very remarkable results.
This video: What is Large Granular Lymphocytic Leukemia (LGLL)?' is a comprehensive talk explaining what LGLL is (in plain English so everyone can understand), the pathophysiology, some genetics and immunology, the most common treatment medications that are used currently, and treatment for refractory LGLL.
Chapters:
0:00 Intro: Dr. Shauna Collins in the hospital
2:25 What is Large Granular Lymphocytic Leukemia (LGLL)?
5:59 STAT Mutations
7:46 Constitutive STAT activation and Resistance to Apoptosis (via survival pathways)
8:28 Review of blood cell lines
9:45 Neutrophil-Lymphocyte distribution: Normal vs in LGLL
10:05 LGLL Diagnostic Criteria
10:47 Flow Cytometry - used to identify cells of the immune system
12:57 Flow Cytometry quantifies LGL cells
13:38 Sharing my personal Flow Cytometry report
14:46 Sharing my personal bone marrow pathology report
15:50 Normal TCR Gene Rearrangement
16:50 Sharing my personal T-Cell Receptor (TCR) Test
16:58 LGLL Treatment
17:54 Choosing optimal treatment depends on LGLL manifestations and comorbidities.
19:01 Treatment for Refractory LGLL
19:32 Interrupted by Nurse to receive IV Steroid; The Effects of Steroids
20:23 Conclusion
I created this presentation (from my hospital bed during my 10-day hospital admission for LGLL-associated acute hemolytic anemia) because there's very little easy-to-understand information about LGLL available online. So I did my best to provide detailed information about LGLL in layman's terms so that all LGLL patients and their beloved friends and family members can better understand this disease. I truly hope it's helpful to people! I'd greatly appreciate your feedback in the comments if you benefited from this information!
You'll want to watch:
These Cancer Symptoms Ruined Life as I Knew it - Large Granular Lymphocytic Leukemia (LGLL)
https://youtu.be/M6WROGXOjqI
My Cancer Journey: The Effect of Juicing on Large Granular Lymphocytic Leukemia (LGLL)
https://youtu.be/crkjEXIJn1U
Leukemia Cancer Survivor - My 10 Day Hospital Stay (LGLL) - PART 1
https://youtu.be/E76dYuVL1jw
Leukemia Cancer Survivor - My 10-day Hospital Stay (LGLL) - Part 2
https://youtu.be/pLfQ3x1HweU
All cancer-related videos are found in the playlist:
CANCER-LARGE GRANULAR LYMPHOCYTIC LEUKEMIA (LGLL)
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Hi, my name is Shauna Collins and I have cancer. I happen to be a medical doctor as well. I have a very rare leukemia called 'Large Granular Lymphocytic Leukemia' (LGLL). Most of my LGLL videos are extremely candid and very, very personal. They document my personal cancer journey - the good, the bad and the ugly. I also explain how I've addressed this cancer with nutrition and juicing with some (but not all) very remarkable results. I take you into my own kitchen and show you exactly what produce we juice. I show you my actual lab reports and tests and you see what elements of my LGLL cancer have tremendously improved with juicing and which have not. Also, being a physician (UCLA Med School graduate) I study quite a bit of LGLL literature and teach you about LGLL because it's so rare and there is not a lot of information on the internet about it.
All of this sharing is purely an act of love for whoever may benefit.
God bless you!
Doc Shauna
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