CD30+ lymphoproliferative disorders, lymphomatoid papulosis, anaplastic large cell lymphoma

This part 5 of our video series on cutaneous T cell lymphomas.
In this video, we focus on CD30+ lymphoproliferative disorders, including lymphomatoid papulosis and cutaneous anaplastic large cell lymphoma.

Lymphomatoid papulosis
- Lymphomatoid papulosis is a chronic papulonecrotic or papulonodular skin disease with histologic features suggestive of a malignant lymphoma
- The disease is characterized by recurrent crops of pruritic papules at different stages of development that predominately arise on the trunk and limbs
- The papules heal spontaneously over 1-2months, usually leaving slightly depressed oval scars
- Typical waxing and waning course
- Lymphomatoid papulosis is part of the CD30+ lymphoproliferative diseases

Cutaneous anaplastic large cell lymphoma
- Anaplastic large cell lymphomas are distinguishable from other lymphomas by their anaplastic cytology and constant membrane expression of CD30 antigen
- Primary cutaneous CD30+ anaplastic large cell lymphoma is defined by skin-only involvement without systemic dissemination at presentation
- The involvement of draining regional lymph nodes occurs in approx 25% pts with skin-only lesions

Disclaimer: This video is for education and entertainment purposes only and does not constitute medical advice. The information available on this channel does not offer a diagnosis or advice regarding treatment, and is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal. Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.

Images disclaimer: Images are used from the public domain and used in accordance with Fair Use laws and are intended for educational/teaching purposes only.


#dermatology #residency #usmle #skincare #internalmedicine #health
#doctor #medicaleducation #healthcare #internalmedicineeducation
#medicalschool #skin #acne #beauty #cosmetics #skinhealth #dermatologist #skintreatment

• Category

  Cutaneous T-Cell Lymphoma