Universal Screening for Lynch Syndrome in Endometrial Cancers
Casey Cosgrove, MD, a fellow at the Ohio State Comprehensive Cancer Center, discussed a pilot trial that screened patients with endometrial cancers for Lynch syndrome.The potential impact of this study could lead to the prevention of endometrial, ovarian, and colorectal cancers in the future, Cosgrove said.
With over 60,000 cases of endometrial cancers occurring per year, screening has been recommended by several organizations. In this pilot study, Cosgrove completed testing on all endometrial patients at Ohio State by using immunohistochemistry and microsatellite stability testing.
If patients were found positive for Lynch syndrome, they then underwent germline testing to investigate whether or not the patient was born with the disease or not. Tumor testing was used to consolidate findings if the reason for mutations did not appear in the previous screenings.
Overall, Cosgrove concluded, a 3% chance for Lynch syndrome was found, which was consistent with previous data. He also added that this means about 4 family members will be affected by Lynch syndrome. This data can be used in combination with the current strategies available for treating these types of cancers.
For more resources and information regarding anticancer targeted therapies in gynecologic cancers: http://www.targetedonc.com/res....ource-center/gynecol
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