Transplantation for Myelodysplastic Syndromes (MDS): Who, When and How 2021

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07/04/23

Summary: Myelodysplastic syndrome (MDS) is a blood disorder that can develop into leukemia. There are several treatments for MDS, including stem cell transplantation. This presentation reviews key features of MDS, treatment options and when a transplant is an appropriate remedy.

Presenter:
Nandita Khera MD, MPH, Blood and Marrow Transplant Clinical Trials Network Evidence into Practice Task Force

Highlights:

MDS patients are categorized into risk groups based on their blood counts, number of abnormal cells, genetic mutations, and chromosomal changes. Patients with low-risk disease rarely develop full blown leukemia, whereas those with high-risk disease will likely develop leukemia.
Allogeneic transplant (a transplant using donor stem cells) is the only potential cure for MDS.
All medically eligible, high risk, MDS patients, including older adults, should be evaluated for transplant.

To read the transcript, go to: https://www.bmtinfonet.org/vid....eo/transplantation-m

This is a recording of the live webinar that occurred on October 26, 2021.

Key Points:

(03:03) MDS involves low blood counts, marrow dysplasia, and genetic mutations.

(03:41) MDS affects about 60,000 people in the U. S, typically older adults.

(05:49) Treatment options depend on the how likely it is that the disease will progress to leukemia and include supportive care, gentle chemotherapy or transplant.

(09:57) A recent observational study showed comparable survival rates for younger and older patients who received transplants.

(11:09) A recent clinical trial found patients with advanced MDS who received transplants did much better than those who did not.

(14:41) Transplants using half-matched or unrelated donors have comparable outcomes to those with matched donors.

(17:29) Considering all options (including half-matched relatives), most candidates for transplant will have a suitable donor.

(17:54) Transplant requires conditioning with chemotherapy and radiation to prepare the body for new stem cells.

(21:48) Transplants are more successful if the patient is in remission at transplant; other factors also play a role.

Meet the speaker: Nandita Khera MD
https://www.mayoclinic.org/bio....graphies/khera-nandi

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