Q&A Session - Sarcoma Exchange 2022
Question & Answer Session with Dr. Gina D'Amato @SylvesterCancer, Dr. Charles Forscher @cedarssinai, Dr. Mark Agulnik and Dr. Lee Zuckerman, @cityofhope
Question Timestamps:
00:00:26 - Are there any clinical trials targeting the following genomic mutations: KEAP1 or PIKER1 for metastatic spindle cell sarcoma? When sending a tissue sample for genomic testing, does one go for the initial primary tumor or the metastatic tumor type (e.g. pulmonary)? Does the primary tumor type have any influence on targeted therapy? Is it usually the same mutation as the secondary sites?
00:03:26 - Did the cutaneous angiosarcoma study drop the third arm?
00:04:31 - I have PEComa that has metastasized from my uterus to both my lungs. Would either Keytruda or Ivermectin be of some help with getting results with other treatments also? I've read about these drugs lately. I've been stage IV for two years now.
00:06:56 - What are the benefits of genetic or mutation testing? And do doctors usually prescribe treatment based on this result?
00:09:55 - What is the frequency of checking on clinical trial patients to see how they're progressing, if they're getting better, or things aren't going great? How often are they examined?
00:13:03 - How long could someone with a retroperitoneal sarcoma that has metastasized to the lungs be on any given therapy?
00:15:21 - Which immunotherapy drugs are helpful for recurrent, metastatic, inoperable sclerosing epithelioid fibrosarcoma (SEF)?
00:17:37 - What does standard treatment mean? What's usually done and has it been validated for rare cases of sarcoma?
00:19:44 - Do leiomyosarcoma treatments work on PEComa cells?
00:22:03 - How long does it take for clinical trial data to be shared with doctors and patients? When treatments primarily used for other types of cancer are used on sarcoma, how is that data shared?
00:29:29 - From A to Z, what's the average time for a drug to be put on the market?
00:32:50 - How do placebos work? Do patients know they're going to be subjected to placebos?
00:36:18 - When interpreting genomic testing, what is the significance of tumor mutational burden value?
00:37:58 - Have any therapeutics used to treat lung cancer been effective in patients with pulmonary metastases?
00:40:08 - I have retroperitoneal leiomyosarcoma that has metastasized to my lungs. I'm not sure if my doctor has done next generation sequencing or genetic testing on the tumor that I most recently had removed. If they won't offer or cover that service for me, is the a program that will?
00:42:40 - If a patient has been hugely helped by an off-label drug for their cancer where the treatment was mostly historical, rather than validated, what can that person do to be of help to others with that cancer?
00:44:32 - Is stereotactic body radiation therapy (SBRT) really helpful in multiple metastatic soft tissue sarcomas?
July 23, 2022 - Sarcoma Exchange 2022 - Day 1
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