Pegenzileukin for T-cell dysfunction

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07/14/23

T-cell dysfunction from chronic antigen stimulation limits the efficacy of T-cell therapies. Pegenzileukin (formerly known as SAR444245) is a non-alpha IL2, that rescues chronic antigen and CAR-driven T-cell dysfunction in T-cell assays taken from donors. In this video, Michael Green, PhD, University of Texas MD Anderson Cancer Center, Houston, TX, discusses T-cell dysfunction and the potential use of pegenzileukin to mitigate the issues this dysfunction causes. This interview took place at the 17th International Conference on Malignant Lymphoma (ICML), held in Lugano, Switzerland.

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