Medical Genetics of Acute Myeloid Leukemia

https://www.amazon.com/Medical....-Genetics-Acute-Myel This article collection reviews the medical genetics of acute myeloid leukemia and includes 30 papers by various authors. Topics include: Molecular and genetic alterations associated with therapy resistance and relapse of acute myeloid leukemia; Next Generation Sequencing of Acute Myeloid Leukemia: Influencing Prognosis; Genetic alterations of m6A regulators predict poorer survival in acute myeloid leukemia; Identification of somatic mutations using whole-exome sequencing in Korean patients with acute myeloid leukemia; Clinical implications of genome-wide DNA methylation studies in acute myeloid leukemia; A WIMSical approach to decoding DNA methylation in myeloid leukemia; A three-gene expression-based risk score can refine the European LeukemiaNet AML classification; A de novo acute myeloid leukemia (AML-M4) case with a complex karyotype and yet unreported breakpoints; Acute myeloid leukemia - strategies and challenges for targeting oncogenic Hedgehog/GLI signaling; Implementation of next generation sequencing into pediatric hematology-oncology practice: moving beyond actionable alterations; Microarray-based analysis and clinical validation identify ubiquitin-conjugating enzyme E2E1 (UBE2E1) as a prognostic factor in acute myeloid leukemia; The promoter of miR-663 is hypermethylated in Chinese pediatric acute myeloid leukemia (AML); Homeobox gene expression in acute myeloid leukemia is linked to typical underlying molecular aberrations; Mutations in the isocitrate dehydrogenase 2 gene and IDH1 SNP 105C T have a prognostic value in acute myeloid leukemia; Rare MLL-ELL fusion transcripts in childhood acute myeloid leukemia - association with young age and myeloid sarcomas?; Analyzing the gene expression profile of pediatric acute myeloid leukemia with real-time PCR arrays; Computational identification of the normal and perturbed genetic networks involved in myeloid differentiation and acute promyelocytic leukemia; Current findings for recurring mutations in acute myeloid leukemia; Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications; Molecular alterations of isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) metabolic genes and additional genetic mutations in newly diagnosed acute myeloid leukemia patients; Molecular prognostic markers for adult acute myeloid leukemia with normal cytogenetics; Long noncoding RNAs: pivotal regulators in acute myeloid leukemia; CYP1A1 MspI polymorphism and acute myeloid leukemia risk: meta-analyses based on 5018 subjects; TP53 mutation characteristics in therapy-related myelodysplastic syndromes and acute myeloid leukemia is similar to de novo diseases; A case of acute myeloid leukemia (AML) with an unreported combination of chromosomal abnormalities: gain of isochromosome 5p, tetrasomy 8 and unbalanced translocation der(19)t(17;19)(q23;p13); Hypomethylation and expression of BEX2, IGSF4 and TIMP3 indicative of MLL translocations in Acute Myeloid Leukemia; 5'UTR point substitutions and N-terminal truncating mutations of ANKRD26 in acute myeloid leukemia; Analysis of AML genes in dysregulated molecular networks; SLC29A1 single nucleotide polymorphisms as independent prognostic predictors for survival of patients with acute myeloid leukemia: an in vitro study; and A novel BCR-ABL1 fusion gene identified by next-generation sequencing in chronic myeloid leukemia.

• Category

  Leukemia - Acute Myeloid - AML - Childhood