Li-Fraumeni syndrome-associated dimer-forming mutant p53 promotes transactivation-independent mi...
Dr Joshua Choe speaks to ecancer as part of AACR 2023 about a study which showed Li-Fraumeni syndrome-associated dimer-forming mutant p53 promotes transactivation-independent mitochondrial cell death.
He explains that individuals with Li-Fraumeni syndrome are pre-disposed to a spectrum of cancers such as sarcomas and gliomas. The study aimed to understand how the gain of function or loss of function activities of p53 contributes to tumour genesis.
Dr Choe then outlines the study design and key findings.
He concludes by describing the next steps for this study and the potential impact these results may have on future research into mutant p53 variants.
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