How PSA Responds to #ProstateCancer Treatment | #MarkScholzMD #AlexScholz #PCRI

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07/07/23

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In this video, medical oncologist, Mark Scholz, MD, explains how PSA is used to monitor a prostate cancer patient during and after the various treatments for prostate cancer patients. He covers monitoring patients after surgery, radiation, hormone therapy, chemotherapy, immune therapy, and radioligand treatments like Xofigo and Lutetium-177.

0:55 How is PSA used to monitor whether hormone therapy is effective?

2:38 Are there any major differences between the various "first-generation" hormone therapies? First-generation hormone therapies are ones like Lupron, Trelstar, and Firmagon which are used to stop the testicular production of testosterone.

3:39 Can PSA response be used to determine whether a more potent second-generation hormone therapy should be added to a person's therapy?

5:03 In what timeframe should a man expect his PSA to reach its nadir (low-point) after radical prostatectomy (surgery) for prostate cancer?

6:46 What kind of PSA decline should a person expect after radiation? Does it matter which form of radiation is used?

8:31 How does a person use PSA after focal therapy? Focal therapy is a form of treatment to a portion of the prostate itself and is contrasted with "radical therapy" which means treatment of the entire prostate gland.

10:24 What is "PSA density?" How is it relevant to monitoring men after focal therapy?

11:40 How is PSA used to monitor whether treatments like Provenge are working since they do not always cause an immediate PSA decline?

14:09 How do you know if Xofigo is working if it does not cause a PSA decline?

15:07 How is PSA used to monitor chemotherapy patients? What kind of PSA decline do you expect to know if it is working?

16:39 What kind of PSA decline do you expect after Lutetium-177?

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