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Genetic Relationship with Acute Myeloid Leukemia
Link : www.genedent.com
Narration by : Geetika Raj ( Scientific Co-ordinator at Kroynas)
What is it?
Acute myeloid leukemia (AML) is a type of cancer that affects the blood and bone marrow, where blood cells are produced. In AML, abnormal blood cells, usually immature white blood cells called myeloblasts, rapidly accumulate in the bone marrow and interfere with the production of normal blood cells, such as red blood cells and platelets.
What are its causes?
The exact cause of AML is unknown, but several factors can increase the risk of developing the disease. These include exposure to radiation, chemicals such as benzene, certain chemotherapy drugs, smoking, and certain genetic disorders.
What are the genes behind it?
AML is associated with mutations in genes that regulate the growth and differentiation of blood cells. Some of the most common genes mutated in AML include FLT3, NPM1, and CEBPA. Mutations in these genes can lead to uncontrolled growth and accumulation of abnormal blood cells.
What are its symptoms?
The symptoms of AML can vary depending on the stage and severity of the disease. Common symptoms include fatigue, weakness, shortness of breath, fever, unexplained weight loss, easy bruising or bleeding, and frequent infections. Some patients may also experience bone pain, swollen lymph nodes, or an enlarged spleen.
What is its treatment?
The treatment of AML typically involves chemotherapy to kill cancer cells and promote the growth of healthy blood cells. Depending on the subtype and stage of the disease, other treatments may include radiation therapy, targeted therapy, or stem cell transplant. The choice of treatment depends on several factors, including the patient's age, overall health, and genetic profile. AML can be a difficult disease to treat, and the prognosis varies depending on several factors, including the subtype and stage of the disease, the patient's age, and overall health.
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