Colorectal cancer statistics, 2023 | Prof Luigi Fontana
Although overall Colorectal cancer (CRC) mortality continues to decline, this progress is tempered by a rapidly changing landscape of disease that foreshadows less favorable trends ahead. First, the CRC burden is shifting to younger individuals as cohorts born in the last one half of the 20th century who have elevated risk age; one in five new cases now occur in individuals in their early 50s or younger. Second, there is an overall shift to later stage disease, with more individuals now diagnosed at an advanced stage than in the mid-1990s before widespread screening. Finally, there is a shift from right-sided to left-sided tumors, despite higher efficacy for preventing the latter through screening, likely reflecting changes in underlying disease risk of unknown etiology.
I would like to remind all of you that Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the third most common cause of cancer-related death in both men and women in the United States. However, it ranks second in cancer-related deaths overall and is the leading cause in men younger than 50 years. More than one half of all cases and deaths are attributable to modifiable risk factors, such as smoking, an unhealthy diet, high alcohol consumption, physical inactivity, and excess body weight.
https://acsjournals.onlinelibr....ary.wiley.com/doi/10
As I have explained in my scientific articles and books this disease can be prevented through tailored lifestyle, mechanism-based interventions, such as dietary restriction, high fiber plant based diets with optimal intake of protein and specific amino acids, regular exercise training.
https://pubmed.ncbi.nlm.nih.gov/20097433/
https://pubmed.ncbi.nlm.nih.gov/34518687/
https://pubmed.ncbi.nlm.nih.gov/34383300/
https://amzn.asia/d/f98GIcR
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