Cervical Cancer part 2 : Obstetrics and gynaecology Video lectures ( Medvizz app )

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07/03/23

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Cervical Cancer part 2 : Obstetrics and gynaecology Video lectures ( Medvizz app )

The incidence and prevalence of cervical cancer have decreased significantly due to effective screening measures and vaccine development.
Because screening detects very early changes in the cervical epithelium, most patients diagnosed with cervical cancer are asymptomatic.
The human papillomavirus (HPV) is the primary cause of cervical cancer.
HPV inhibits the tumor suppressor proteins Rb and p53, which affects progression from the G1 phase to the S phase in the cell cycle and allows rampant cell growth.
Cervical cancer is a carcinoma arising from the cervical epithelium, most often at the squamocolumnar junction where the squamous epithelium of the ectocervix transitions to the columnar epithelium of the endocervix.
The Pap test is an important screening tool for cervical cancer.
Results are graded as LSIL, HSIL, or ASCUS. Biopsy specimens are graded histologically according to depth and are reported with CIN grades.
The HPV vaccine is a recombinant vaccine that protects against cervical cancer.
Treatment of cervical dysplasia and cancer varies by grade and stage and can include local treatment, surgery, or chemotherapy and radiation.

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