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Can you identify the type of leiomyoma based on morphology?
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• 07/10/23
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Try to identify the leiomyoma based on the morphology
1. Staghorn vasculature
2. Bizzare nuclei
3. Eosinophilic nucleoli surrounded by a halo
It is Fumarate hydratase deficient leiomyoma.
Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome is a rare autosomal dominant disease caused by germline mutations in the fumarate hydratase (FH) gene. Affected individuals develop cutaneous and uterine leiomyomas and aggressive RCC.
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