Adenoid Cystic Carcinoma,etiopathogenesis,Histopathology,clinical features,MCQs,Treatment&Progno
Adenoid Carcinoma
Prof Mulazim Hussain Bukhari
Definition: A carcinoma of primary salivary gland or minor salivary gland of upper aerodigestive tract characterized by its biphasic ductal and myoepithelial differentiation, tubular / cribriform / solid architecture.
May occur in major and minor salivary glands
(1)Among major salivary glands, the most commonly affected site is the parotid gland
(2) Minor salivary glands that may be affected include those of oral cavity, sinonasal tract, nasopharynx, oropharynx and trachea.
Essential features
(1) Grows in tubular, cribriform, and/or solid patterns: solid pattern is associated with adverse outcome
(2) 60% - 90% carry MYB-NFIB or MYBL1-NFIB fusion
(3) Biphasic tumor showing ductal and myoepithelial differentiation
(4) Frequent perineural invasion. common it is in the world
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