HHV-8 is a gamma herpesvirus and it can also cause cancer in immunocompromised hosts, like EBV. It causes Kaposi Sarcoma, a cancer of endothelial cells. For more videos and questions, visit - https://www.macrophage.co. Subscribe - https://goo.gl/EMRlRa. Support us on Patreon - https://goo.gl/bhmrgJ.

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Kaposi Sarcoma ( Part 5 ) : AIDS associated kaposi sarcoma : USMLE Step 1 Pathology

AIDS-related or epidemic KS – AIDS-related or epidemic KS is the most common tumor arising in HIV-infected persons. KS is considered an AIDS-defining illness in the United States Centers for Disease Control and Prevention (CDC) guidelines. In the United States, KS was over 20,000 times more common in persons with AIDS than in the general population prior to the widespread use of potent antiretroviral therapy (ART), although its incidence has declined substantially since that time.

Epidemiology of AIDS-related KS — Although KS has been reported among all risk groups for HIV infection, it is most common in homosexual or bisexual men. AIDS-related KS is much less common in heterosexual injection drug users, transfusion recipients, women or children, and hemophiliacs .

In patients with AIDS-related KS, the CD4 count appears to be an important factor associated with the development of KS. In a series of 70 patients who presented with a new diagnosis of KS while on treatment with combined ART, the rate ratios for developing KS for patients with CD4 counts greater then 200, 200 to 349, and 350 to 499 cells/mm3 were 18.9, 3.6, and 4.1, compared with those with greater than or equal to 500 cells/mm3

However, trends in earlier initiation of ART and improved health care continuity have altered the epidemiology of AIDS-related malignancies. In a study including 466 patients with AIDS-related KS, less than half of KS cases diagnosed between 2007 and 2011 were in patients with CD4 counts greater then 200, with 29 percent having a viral load greater then 500 copies/mL . This reflects the growing proportion of the HIV population that, due to ART, has higher CD4 counts and suppressed viral loads, rather than an increased risk of cancer among such patients. In resource-rich areas, AIDS-related KS is predominantly a disease of men. In contrast, in resource-poor areas such as sub-Saharan Africa, AIDS-related KS is also more frequent in males, although the difference is less pronounced.

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Covered in this video: Kaposi Sarcoma, HHV-8, DNA virus, linear virus, double stranded, dark purple skin plaques, endothelial neoplasia, kaposi sarcoma, AIDS, HIV, immunocompromised

Kaposi Sarcoma causes, clinical features, assessment, and management with mnemonics for medical students and nursing students.

0:00 Introduction
0:28 Pathogenesis
1:08 Clinical Features
2:05 Investigations
2:21 Management
2:57 Mnemonic
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Excerpted from my dermpath board review video (https://youtu.be/Q88yDU-Pyis) for my 5-Minute Pathology Pearls video series.

A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: https://kikoxp.com/posts/5084 (dermpath) & https://kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).

Here's a full Kaposi sarcoma video: https://kikoxp.com/posts/3706

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Also, check out my full length vascular tumors 101 video: https://kikoxp.com/posts/4070

Awesome examples of vascular lesions (WSI digital slides & videos):
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- Bacillary angiomatosis: https://kikoxp.com/posts/2258
- Epithelioid hemangioendothelioma: https://kikoxp.com/posts/3031
- Kaposi sarcoma 101 video (derm & path): https://kikoxp.com/posts/3706
- Microvenular hemangioma: https://kikoxp.com/posts/3184
- Post-radiation atypical vascular lesion: https://kikoxp.com/posts/3030
- Spindle cell hemangioma: https://kikoxp.com/posts/3074

Please check out my Soft Tissue Pathology & Dermatopathology survival guide textbooks: http://bit.ly/2Te2haB

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Kaposi sarcoma (KS) is a cancer that causes patches of abnormal tissue to grow under the skin, in the lining of the mouth, nose, and throat, in lymph nodes, or in other organs. These patches, or lesions, are usually red or purple. They are made of cancer cells, blood vessels, and blood cells.

KS is caused by infection with human herpesvirus-8 (HHV-8). Most people infected with HHV-8 don't get KS. It usually happens in

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People with weak immune systems, due to HIV/AIDS, drugs taken after an organ transplant, or another disease
Older men of Jewish or Mediterranean descent
Young men in Africa
The skin lesions may not cause symptoms. But they can spread to other parts of the body, especially in people with HIV/AIDS. If they spread to the digestive tract or lungs, they can cause bleeding. Lesions on the lungs can also make it hard to breathe.

Treatment depends on where the lesions are and how bad they are. Options include radiation therapy, surgery, chemotherapy, and biologic therapy. People with HIV/AIDS also take HIV/AIDS medicines. internal medicine

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Kaposi Sarcoma Associated Herpes virus (HHV 8): Morphology, Diagnosis, Treatment & Prevention
This video will teach you everything important about KAPOSI’S SARCOMA, or Human Herpes Virus 8 infection - it’s transmission, pathogenesis, diagnosis and treatment - all in 2 MINUTES!!



If you like this video, do check out our other concise microbiology videos, we’re sure you’ll love them! https://www.youtube.com/playli....st?list=PLCdGGycQr4g



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Kaposi Sarcoma
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