Watch the Full Video at https://www.jove.com/v/54828/an-vitro-model-for-studying-cellular-transformation-kaposi-sarcoma?utm_source=youtube&utm_medium=social_global&utm_campaign=reseach-videos-2022.

An In Vitro Model for Studying Cellular Transformation by Kaposi Sarcoma Herpesvirus - a 2 minute Preview of the Experimental Protocol

Shane C. McAllister, Ryan S. Hanson, Kyleen N. Grissom, Sara Botto, Ashlee V. Moses
University of Minnesota Medical School, Division of Pediatric Infectious Diseases; Oregon Health and Science University, Vaccine and Gene Therapy Institute;

Kaposi sarcoma (KS) is a tumor induced by infection with the oncogenic virus human herpesvirus-8/KS herpesvirus (HHV-8/KSHV). The endothelial cell culture model described here is uniquely suited for studying the mechanisms by which KSHV transforms host cells.

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Este vídeo é sobre Sarcoma. Qual a causa?

Muitas pessoas com diagnóstico de Sarcoma têm a dúvida de como surgiu este tumor?

Existem alguns fatores de risco relacionados aos sarcomas que serão ditos no vídeo, mas a realidade é que em muitos dos casos não sabemos a causa do surgimento dos Sarcomas.

Alguns pacientes poderão ter alterações genéticas que favorecem o seu aparecimento e poderão transmitir o risco para seus descendentes, mas na maioria dos casos isto não acontece.

Os principais fatores de risco para o aparecimento dos sarcomas são:
- Radioterapia prévia.
- Síndromes genéticas.
- Linfedemas.
- HIV/ AIDS

Veja mais informações no vídeo!


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Sarcomas
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Oncologia Ortopédica
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Quadril
https://www.youtube.com/playli....st?list=PLl7GaKfEgTd



🔥 Veja meu site com muito mais informação sobre Doenças do Quadril, Oncologia Ortopédica, Sarcomas e Tumores ósseos.

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💡 Vídeos de assuntos frequentes:

Guia completo sobre a cirurgia de Prótese de Quadril
https://www.youtube.com/watch?v=XhZ82TQ7T5w

Sarcomas
https://www.youtube.com/watch?v=kwN2Yi9e2KI

Qual o preço de uma cirurgia de prótese de Quadril?
https://www.youtube.com/watch?v=tLIGjjul4_A

Fratura de Fêmur em Idosos
https://www.youtube.com/watch?v=P-pQv59D1eU

Câncer nos ossos- 7 Sinais e Sintomas:
https://www.youtube.com/watch?v=qMyLqTpTFaI

📌 𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:- https://www.instagram.com/drgbhanuprakash
📌𝗝𝗼𝗶𝗻 𝗢𝘂𝗿 𝗧𝗲𝗹𝗲𝗴𝗿𝗮𝗺 𝗖𝗵𝗮𝗻𝗻𝗲𝗹 𝗛𝗲𝗿𝗲:- https://t.me/bhanuprakashdr
📌𝗦𝘂𝗯𝘀𝗰𝗿𝗶𝗯𝗲 𝗧𝗼 𝗠𝘆 𝗠𝗮𝗶𝗹𝗶𝗻𝗴 𝗟𝗶𝘀𝘁:- https://linktr.ee/DrGBhanuprakash

Kaposi sarcoma ( Part 6 ) : Diagnosis and staging of kaposi sarcoma : Pathology USMLE Step 1

Kaposi sarcoma

Definition:
• malignant, multifocal, highly vascularized tumor caused by the human herpesvirus 8 (HHV8 )

Classification:
• HIV-associated Kaposi sarcoma

Clinical features
• Multiple cutaneous or visceral, elevated tumors with rapid growth
• Initial manifestation on skin and mucosae (especially face/oral cavity and chest)
• Over time, organ involvement is possible.
• If the gastrointestinal tract is involved: abdominal pain and diarrhea, possibly hemorrhage and bowel obstruction if severe

Diagnostics
• Skin biopsy: spindle-shaped cells, leukocyte infiltration, and angiogenesis.
• Chest x-ray, sonography of the abdomen and lymph nodes

Treatment
• Treatment of the underlying disease → antiretroviral treatment in HIV patients
• Symptomatic therapy:
• Local: intralesional administration of vinblastine or radiation therapy
• Systemic: pegylated liposomal doxorubicin or liposomal daunorubicin
• Prognosis: very variable

#usmleVIDEOS #usmlelectures #pathologyVIDEOS #pathovideos #patholectures #cardiologyvideos #cardiologylectures #kaposisarcoma #usmlestep1videos #usmlestep1lectures

What are vascular tumors? Vascular tumors are usually the result of blood vessel endothelial cell growth and can be benign or malignant, and often manifest as lesions on the skin.

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Sorry for the constant clearing of throat (getting over URI/bronchitis).

Kaposi Sarcoma, nodular (tumoral) stage

This lesion is seen less nowadays since the widespread use of antivirals in the treatment of HIV/AIDS. In the US Kaposi Sarcoma is considered an AIDS-defining lesion (associated with AIDS) and is due to the virus HHV8 (humans herpesvirus 8).
The lesions present as red to purple, asymptomatic blotch/bruise. They can involve the skin as well as mucous membranes (mouth) and internal organs in later stages.

The lesions go through a few phases: patch (flat area of discoloration greater than 1 cm), plaque (thicker and lifted lesion greater than 1 cm), and nodular as in this case. Patch and plaque phases look quite similar microscopically. Nodular phase is distinct.

Microscopically (nodular stage):

1. The biggest clue is hemorrhage (RBC outside of blood vessels) within a vascular lesion. Most hemangiomas do not have red cell extravasation.
2. The lesion is within the dermis and is well circumscribed pink spindled cells with extravasated red cells. Spindled cells often run parallel to each other.
3. May see irregular slit-like vascular spaces within the main part of the lesion.
4. Mitoses
#dermatology #skin #health #medical #medstudent #science #histology #pathology #dermpath

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