Learn what is chronic myelogenous leukemia as well as how to identify its signs and symptoms, diagnose it, and treat it. By Raja Narayan. Visit us (http://www.khanacademy.org/sci....ence/healthcare-and- for health and medicine content or (http://www.khanacademy.org/test-prep/mcat) for MCAT related content. These videos do not provide medical advice and are for informational purposes only. The videos are not intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of a qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read or seen in any Khan Academy video. Created by Raja Narayan.

Watch the next lesson: https://www.khanacademy.org/test-prep/nclex-rn/hematologic-system-diseases/rn-myeloproliferative-disorders/v/what-is-primary-myelofibrosis?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn

Missed the previous lesson? https://www.khanacademy.org/test-prep/nclex-rn/hematologic-system-diseases/rn-myeloproliferative-disorders/v/what-is-essential-thrombocythemia?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn

NCLEX-RN on Khan Academy: A collection of questions from content covered on the NCLEX-RN. These questions are available under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 United States License (available at http://creativecommons.org/lic....enses/by-nc-sa/3.0/u

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This clip is an excerpt from a Hemepath Board Review video by special guest, Dr. Jeanette Ramos (full video here: https://kikoxp.com/posts/3726). If you missed Dr. Ramos's first guest lecture discussing the histology and immunostaining patterns of non-neoplastic lymph nodes, check it out here: https://kikoxp.com/posts/4068.

If you like Dr. Ramos's cases and teaching style, be sure to follow UAMS Hematopathology on social media, as she often contributes to their accounts:
- https://twitter.com/hemepathuams
- https://www.facebook.com/hemepathUAMS/

A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: https://kikoxp.com/posts/5084 (dermpath) & https://kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).

This video is geared towards medical students, pathology/internal medicine/family practice residents, hematology or hematopathology fellows, or practicing pathologists or hematologists. Of course, this video is for educational purposes only and is not formal medical advice or consultation. Neither Dr. Ramos nor Dr. Gardner have any special inside knowledge of the content of the path/heme/hemepath/USMLE board examinations. This video is subjectively labeled as a "board review" purely because we believe these topics are potentially testable entities, not because we have any knowledge about the frequency that they will show up on actual board exams.

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Chronic myeloid leukemia (CML) is also known as chronic myelogenous leukemia. It's a type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood. About 15% of leukemias in adults are CML.
Learn more about CML. Find list of expert doctors, hospitals and ongoing clinical trials - https://www.xpertdox.com/disea....se-description/Chron

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- With Picmonic, get your life back by studying less and remembering more. Medical and Nursing students say that Picmonic is the most comprehensive and effective way to bridge learning and test prep...
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►👨‍🏫💊Antibiotics Lectures: https://www.medicosisperfectio....nalis.com/products/c ... ❗️Sorry! I made a MISTAKE in this video!
The mistake: CML is characterized by increased number of neutrophils.
The correction: CML is characterized by increased number of basophils.

Check out my brand new "Electrolytes" course at https://www.medicosisperfectio....nalis.com/products/c and use the PROMO code: ELECTROLYTES50 to get a 50% discount. Chronic myeloid leukemia (or chronic myelogenous leukemia or CML) is a chronic leukemia, as well as a myeloproliferative neoplasm (MPNs).

What is chronic myeloid leukemia? --This is the topic of today's video.


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Disclaimer 1: The medical information contained herein is intended for educational purposes only, and are not intended for diagnosis of any illness. If you think you may be suffering from any medical condition, you should consult your physician or seek immediate medical attention.
I am NOT a licensed physician…Talk to your doctor.

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Got a question? Ask it in the comments section below, or connect with me on FACEBOOK https://www.facebook.com/medicosis/ where you can directly message me…I respond to your messages personally. Thanks!

Whether you’re studying for the USMLE, MCAT, shelf exam, NCLEX, COMLEX, PLEB, MCCEE, AMC_CAT, PANCE,…etc., these videos will help! Take it to the bank :)

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Remember, chronic myeloid leukemia (CML) is a chronic leukemia; monoclonal disorder of late hematopoietic stem cells. If you like my videos, please consider leaving a tip at https://www.paypal.me/perfectionalis/
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You can find the NOTES and ILLUSTRATIONS for this lecture on our website at:
https://www.ninjanerd.org/lect....ure/chronic-myeloid-

Ninja Nerds!
In this lecture Professor Zach Murphy will be presenting on Chronic Myeloid Leukemia (CML). CML is a type of cancer that affects the blood and the bone marrow. We hope you enjoy this lecture and be sure to support us below!

Table of Contents:
0:00 Lab
0:07 Chronic Myeloid Leukemia (CML) Introduction
1:10 Hematopoiesis Pathway
12:33 Pathophysiology: Chronic Phase
19:35 Pathophysiology: Accelerated Phase
26:47 Pathophysiology: Blast Phase
31:34 Diagnostic Approach to CML
43:37 Treatment
48:42 Comment, Like, SUBSCRIBE!

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Lesson on Chronic Myeloid Leukemia (CML): Pathogenesis, Symptoms and Treatment. Chronic Myeloid (or Myelogenous) Leukemia (CML) is one type of leukemia, which is a blood cancer with high levels of white blood cells. CML is a leukemia with proliferation of mature neutrophils (PMNs), as evidenced by white blood cells with large nuclei on a blood smear or peripheral blood film. CML often presents asymptomatically, but can progress to having characteristic signs and symptoms of splenomegaly, constitutional symptoms, and lower sternum tenderness.

Pathogenesis of CML is due to the Philadelphia Chromosome, which is a product of translocation of chromosomes 9 and 22, leading to a new fusion gene and protein product. This new protein (BCR-ABL) is an activated tyrosine kinase, which leads to activation of cellular survival and proliferation pathways.

Treatment of CML involves a drug known as imatinib, which has been designed to specifically target the BCR-ABL fusion protein.

I hope you find this video helpful! If you do, please like and subscribe for more lessons like this one :)

Please also check out some of my other hematology videos!

JJ

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Check out some of my other lessons.

Medical Terminology - The Basics - Lesson 1:
https://www.youtube.com/watch?v=04Wh2E9oNug

Fatty Acid Synthesis Pathway:
https://www.youtube.com/watch?v=WuQS_LpNMzo

Wnt/B Catenin Signaling Pathway:
https://www.youtube.com/watch?v=NGVP4J9jpgs

Upper vs. Lower Motor Neuron Lesions:
https://www.youtube.com/watch?v=itNd74V53ng

Lesson on the Purine Synthesis and Salvage Pathway:
https://www.youtube.com/watch?v=e2KFVvI8Akk

Gastrulation | Formation of Germ Layers:
https://www.youtube.com/watch?v=d6Kkn0SECJ4

Introductory lesson on Autophagy (Macroautophagy):
https://www.youtube.com/watch?v=UmSVKzHc5yA

Infectious Disease Playlist
https://www.youtube.com/playli....st?list=PLRjNoiRtdFw

Dermatology Playlist
https://www.youtube.com/playli....st?list=PLRjNoiRtdFw

Pharmacology Playlist
https://www.youtube.com/playli....st?list=PLRjNoiRtdFw

Hematology Playlist
https://www.youtube.com/playli....st?list=PLRjNoiRtdFw

Rheumatology Playlist
https://www.youtube.com/playli....st?list=PLRjNoiRtdFw

Endocrinology Playlist
https://www.youtube.com/playli....st?list=PLRjNoiRtdFw

Nephrology Playlist
https://www.youtube.com/playli....st?list=PLRjNoiRtdFw

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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.

Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.

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*Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.*

I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :) And please don't hesitate to send me any messages if you need any help - I will try my best to be here to help you guys :)

Thanks for watching! If you found this video helpful, please like and subscribe!
JJ