Learn about our dedicated Lynch Syndrome Center - https://www.dana-farber.org/lynchsyndrome Joel Goldberg, MD, MPH, FACS, colorectal surgeon at Brigham and Women’s Hospital, discusses the different decisions faced by patients and physicians when a colorectal surgery is determined to be necessary.

Kimmie Ng, MD, MPH, discusses Lynch syndrome and how it is related to colon cancer.


This is an excerpt from a live video webchat on colon cancer prevention. Watch the full webchat video here: https://www.youtube.com/watch?v=LuWYOYwkH8k

More information on colon cancer treatment and research:
http://www.dana-farber.org/Adu....lt-Care/Treatment-an

Lynch Syndrome, also called hereditary non-polyposis colorectal cancer, is the most common cause of inherited colorectal cancer. Colorectal cancer is the second leading cause of cancer-related death in the United States.

Symptoms of Lynch Syndrome include: abdominal pain, bloody stool and a change in bowel habit patterns.

The lifetime risk of colorectal cancer for Lynch Syndrome varies but can be has high as 47 percent. Colorectal cancer in Lynch Syndrome tends to occur at a younger age (45-60) compared to sporadic colon cancer (69).

While colorectal cancer is the most common, other cancers associated with Lynch Syndrome include: uterine, ovarian, stomach, small bowel, bile duct, ureter, brain, sweat gland tumors.

How is Lynch Syndrome diagnosed?

Different strategies for identifying individuals at risk for Lynch Syndrome consider family history, prediction models, tumor-based testing and genetic analysis. Another commonly used strategy to diagnose Lynch Syndrome is simplified into the "3-2-1 rule". The "3-2-1 rule" means patients at risk for Lynch Syndrome will have: three or more relatives with Lynch Syndrome related cancers, two generations affected by Lynch Syndrome related cancers, and one or more of those cases of cancer were diagnosed before the age of 50.

If you have a family history that includes Lynch Syndrome related cancers, testing should be considered.

If you have questions about your gastrointestinal health and how hereditary conditions may play a part in your overall health, contact the gastroenterologists at Granite Peaks Gastroenterology.

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One of several videos we're posting for #GenomicsConversation week 2023, which has a theme of 'hidden genomics'.

Find out more: https://www.genomicseducation.....hee.nhs.uk/about-us/

This presentation was given at the NHS East Genomics Showcase event held in Peterborough on 4 May 2023.

Our other videos are included in our 'Genomics Conversation week 2023' Playlist.

Read the research: https://doi.org/10.3399/BJGP.2021.0610
In this 1-minute video Kelly E Lloyd explains:
– NICE recommends considering aspirin for patients with Lynch syndrome
– Anyone with colorectal or endometrial cancer should be tested for LS
– GPs could see more cases of Lynch syndrome
– GPs with prior awareness were more comfortable discussing aspirin
– We need more targeted interventions in this area

Listen to the full-length interview: https://player.captivate.fm/ep....isode/c37f7e01-47c7-

Casey Cosgrove, MD, a fellow at the Ohio State Comprehensive Cancer Center, discussed a pilot trial that screened patients with endometrial cancers for Lynch syndrome.The potential impact of this study could lead to the prevention of endometrial, ovarian, and colorectal cancers in the future, Cosgrove said.

With over 60,000 cases of endometrial cancers occurring per year, screening has been recommended by several organizations. In this pilot study, Cosgrove completed testing on all endometrial patients at Ohio State by using immunohistochemistry and microsatellite stability testing.

If patients were found positive for Lynch syndrome, they then underwent germline testing to investigate whether or not the patient was born with the disease or not. Tumor testing was used to consolidate findings if the reason for mutations did not appear in the previous screenings.

Overall, Cosgrove concluded, a 3% chance for Lynch syndrome was found, which was consistent with previous data. He also added that this means about 4 family members will be affected by Lynch syndrome. This data can be used in combination with the current strategies available for treating these types of cancers.

For more resources and information regarding anticancer targeted therapies in gynecologic cancers: http://www.targetedonc.com/res....ource-center/gynecol