Dr. Costas D Lallas, MD FACS
Professor and Vice-Chair of Urology
Thomas Jefferson University

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EJE - Latest Research in less than 2 minutes with EJE CoMICs.

Full text article can be found at:
https://doi.org/10.1093/ejendo/lvad054

The article can be cited as:
Remde H., Schmidt-Pennington L., Reuter R., Landwehr LS., Jensen M., Lahner H., Kimpel O., Altieri B., Laubner K., Schreiner J., Bojunga J., Kircher S., Kunze CA., Pohrt A., Teleanu MV., Hübschmann D., Stenzinger A., Glimm H., Fröhling S., Fassnacht M., Mai K., Kroiss M. (2023). Outcome of immunotherapy in adrenocortical carcinoma: a retrospective cohort study, European Journal of Endocrinology, 188(6):p485-493 https://doi.org/10.1093/ejendo/lvad054

Adrenocortical carcinoma (ACC) is a rare but aggressive malignancy. Recent studies have discovered a pivotal role of the intratumoral microbiota in various cancers, yet it remains elusive in ACC. Here, we explored the intratumoral microbiome data derived from in silico identification, further validated in an in-house cohort by bacterial 16S rRNA fluorescence in situ hybridization and lipopolysaccharide staining. Unsupervised clustering determined two naturally distinct clusters of the intratumoral microbiome in ACC, which was associated with overall survival. The incorporation of microbial signatures enhanced the prognostic performance of the clinical stage in an immunity-dependent manner. Genetic and transcriptomic association analyses identified significant upregulation of the cell cycle and p53 signaling pathways associated with microbial signatures for worsened prognosis. Our study not only supports the presence of intratumoral bacteria but also implies a prognostic and biological role of intratumoral microbiota in ACC, which can advance a better understanding of the biology of ACC.

Yuqing Li, Dengwei Zhang, Minghua Wang, Haowen Jiang, Chenchen Feng, Yong-Xin Li. 2023. Intratumoral microbiota is associated with prognosis in patients with adrenocortical carcinoma. iMeta 2: e102. https://doi.org/10.1002/imt2.102

https://www.amazon.com/Medical....-Genetics-Adrenocort This article collection reviews the medical genetics of adrenocortical carcinoma and includes 12 papers by various authors. Topics include: Adrenal cortical carcinoma with extension into the inferior vena cava – case report and literature review; Implementation of next generation sequencing into pediatric hematology-oncology practice: moving beyond actionable alterations; Diagnostic and prognostic features in adrenocortical carcinoma: a single institution case series and review of the literature; A novel FOXO1-mediated dedifferentiation blocking role for DKK3 in adrenocortical carcinogenesis; Survival and prognostic factors for adrenocortical carcinoma: a single institution experience; TP53 p.R337H is a conditional cancer-predisposing mutation: further evidence from a homozygous patient; A case study of an integrative genomic and experimental therapeutic approach for rare tumors: identification of vulnerabilities in a pediatric poorly differentiated carcinoma; Bilateral adrenocortical carcinoma in a patient with multiple endocrine neoplasia type 1 (MEN1) and a novel mutation in the MEN1 gene; A rare coexistence of non-functional adrenocortical carcinoma and multicentric papillary thyroid microcarcinoma: a case report; Hereditary cancer risk assessment: essential tools for a better approach; The Cancer Genome Atlas Clinical Explorer: a web and mobile interface for identifying clinical–genomic driver associations; Profiling tissue-resident T cell repertoires by RNA sequencing.

Neste vídeo, o Dr.Felipe Machado esclarece algumas dúvidas em relação ao câncer adrenal. Confira!

Dr. Felipe Machado CRM: DF 19.754
Médico Urologista
Clínica Veridium
☎ (61) 2017-2436
📱(61) 99145-4270
💻 https://veridium.com.br/

#Veridium #clinicaveridium #uro #urologista #cancer #canceradrenal #adrenal

Demonstration of the salient microscopic features of adrenocortical adenoma.

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